Osteocalcin immunolabeling during the alveolar healing process in ovariectomized rats treated with estrogen or raloxifene

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dc.contributor.authorLuvizuto, Eloa Rodrigues [UNESP]
dc.contributor.authorDamasio Dias, Sheila Monica [UNESP]
dc.contributor.authorQueiroz, Thallita Pereira [UNESP]
dc.contributor.authorOkamoto, Tetuo [UNESP]
dc.contributor.authorGarcia, Idelmo Rangel [UNESP]
dc.contributor.authorOkamoto, Roberta [UNESP]
dc.contributor.authorDornelles, Rita Cassia Menegati [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2013-09-30T18:29:10Z
dc.date.accessioned2014-05-20T13:43:00Z
dc.date.available2013-09-30T18:29:10Z
dc.date.available2014-05-20T13:43:00Z
dc.date.issued2010-04-01
dc.description.abstractThe influence of an estrogen-deficient state was evaluated in this study and also its treatments with estrogen (E(2)) or with raloxifene (RLX) on the expression of osteocalcin during the periods of the chronology of the alveolar bone healing process (7, 14, 21, 28 and 42 post-extraction days) by means of immunohistochemistry reactions and histomorphometric analysis. Rats (200-220 g) with oestrus cycles normal were either OVX or sham-operated and divided into four groups: sham, OVX control (OVX/O), estrogen (OVX/E(2); 17 beta-estradiol, 400 mu g/mo) and raloxifene (OVX/RLX; 1 mg/kg bw/d) groups. Histomorphometric analysis showed the sham group presented the highest mean value of bone formation post-extraction. The reaction of immunohistochemistry for osteocalcin presented stronger expression of osteocalcin with predominance at 14 and 21 days on sham group. The OVX/RLX group presented better results than OVX/E2, considering the expression of osteocalcin in osteoblastic lineage cells, but still inferior than the sham group. It was concluded that ovariectomy decreases the mineralization process and the osteocalcin expression during the chronology of the alveolar healing process that is not totally recovered with estrogen replacement or raloxifene treatment. (C) 2009 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Estadual Paulista, UNESP, Dept Surg, São Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, UNESP, Integrated Clin, São Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, UNESP, Dent Sch Aracatuba, Dept Basic Sci, São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Dept Surg, São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Integrated Clin, São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Dent Sch Aracatuba, Dept Basic Sci, São Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent1021-1029
dc.identifierhttp://dx.doi.org/10.1016/j.bone.2009.12.016
dc.identifier.citationBone. New York: Elsevier B.V., v. 46, n. 4, p. 1021-1029, 2010.
dc.identifier.doi10.1016/j.bone.2009.12.016
dc.identifier.issn8756-3282
dc.identifier.lattes0169955363968097
dc.identifier.lattes1566928219828056
dc.identifier.lattes5435902422784889
dc.identifier.orcid0000-0003-0783-6612
dc.identifier.urihttp://hdl.handle.net/11449/14964
dc.identifier.wosWOS:000276009400022
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBone
dc.relation.ispartofjcr4.455
dc.relation.ispartofsjr1,652
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectAlveolar processen
dc.subjectOsteocalcinen
dc.subjectOvariectomyen
dc.subjectRaloxifeneen
dc.subjectEstradiolen
dc.titleOsteocalcin immunolabeling during the alveolar healing process in ovariectomized rats treated with estrogen or raloxifeneen
dc.typeTrabalho apresentado em evento
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes0169955363968097
unesp.author.lattes1566928219828056
unesp.author.lattes5435902422784889[7]
unesp.author.orcid0000-0003-0783-6612[7]
unesp.author.orcid0000-0002-2464-8181[3]
unesp.author.orcid0000-0002-6773-6966[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araçatubapt

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