Polymorphisms of DNA repair genes XRCC1 and XRCC3, interaction with environmental exposure and risk of chronic gastritis and gastric cancer

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dc.contributor.authorDuarte, Marcia Cristina [UNESP]
dc.contributor.authorColombo, Jucimara [UNESP]
dc.contributor.authorBaptista Rossit, Andrea Regina
dc.contributor.authorCaetano, Alaor
dc.contributor.authorBorim, Aldenis Albaneze
dc.contributor.authorWornrath, Durval
dc.contributor.authorSilva, Ana Elizabete [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionPio XII Fdn
dc.date.accessioned2014-05-20T15:27:36Z
dc.date.available2014-05-20T15:27:36Z
dc.date.issued2005-11-14
dc.description.abstractAIM: To evaluate the association between polymorphisms XRCC1 Arg194Trp and Arg399Gln and XRCC3 Thr241Met and the risk for chronic gastritis and gastric cancer, in a Southeastern Brazilian population.METHODS: Genotyping by PCR-RFLP was carried out on 202 patients with chronic gastritis (CG) and 160 patients with gastric cancer (GC), matched to 202 (C1) and 150 (C2) controls, respectively.RESULTS: No differences were observed among the studied groups with regard to the genotype distribution of XRCC1 codons 194 and 399 and of XRCC3 codon 241. However, the combined analyses of the three variant alleles (194Trp, 399Gln and 241Met) showed an increased risk for chronic gastritis when compared to the GC group. Moreover, an interaction between the polymorphic alleles and demographic and environmental factors was observed in the CG and GC groups. XRCC1 194Trp was associated with smoking in the CG group, while the variant alleles XRCC1 399Gln and XRCC3 241Met were related with gender, smoking, drinking and H pylori infection in the CG and GC groups.CONCLUSION: Our results showed no evidence of a rela-tionship between the polymorphisms XRCC1 Arg194Trp and Arg399Gln and XRCC3 Thr241Met and the risk of chronic gastritis and gastric cancer in the Brazilian population, but the combined effect of these variants may interact to increase the risk for chronic gastritis, considered a premalignant lesion. Our data also indicate a gene-environment interaction in the susceptibility to chronic gastritis and gastric cancer. (C) 2005 the WJG Press and Elsevier B.V. All rights reserved.en
dc.description.affiliationUNESP São Paulo State Univ, Dept Biol, Campus Sao Jose Rio Pret, SP, Brazil
dc.description.affiliationFAMERP Sao Jose do Rio Preto Sch Med, Microorganism Invest Ctr, Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationHosp Base, FAMERP Sao Jose do Rio Preto Sch Med, Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationPio XII Fdn, Barretos, SP, Brazil
dc.description.affiliationUnespUNESP São Paulo State Univ, Dept Biol, Campus Sao Jose Rio Pret, SP, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent6593-6600
dc.identifierhttp://www.wjgnet.com/1007-9327/full/v11/i42/6593.htm
dc.identifier.citationWorld Journal of Gastroenterology. Beijing: Baishideng Publ Grp Co Ltd, v. 11, n. 42, p. 6593-6600, 2005.
dc.identifier.issn1007-9327
dc.identifier.urihttp://hdl.handle.net/11449/37555
dc.identifier.wosWOS:000208224700005
dc.language.isoeng
dc.publisherBaishideng Publ Grp Co Ltd
dc.relation.ispartofWorld Journal of Gastroenterology
dc.relation.ispartofjcr3.300
dc.relation.ispartofsjr1,409
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectGastric cancerpt
dc.subjectGastritispt
dc.subjectXRCC1pt
dc.subjectXRCC3pt
dc.subjectPolymorphismpt
dc.subjectEnvironmental exposurept
dc.titlePolymorphisms of DNA repair genes XRCC1 and XRCC3, interaction with environmental exposure and risk of chronic gastritis and gastric canceren
dc.typeArtigo
dcterms.licensehttp://www.wjgnet.com/1007-9327/bq.asp
dcterms.rightsHolderBaishideng Publ Grp Co Ltd
unesp.author.lattes2503906319038306[7]
unesp.author.orcid0000-0003-1491-8878[7]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Pretopt

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