Effect of Brazilian propolis on experimental hepatotoxicity in rats

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dc.contributor.authorFernandes, A. A H [UNESP]
dc.contributor.authorFernandes, A. [UNESP]
dc.contributor.authorNovelli, E. L B [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:21:14Z
dc.date.available2014-05-27T11:21:14Z
dc.date.issued2004-12-01
dc.description.abstractPropolis (bee glue) is one of the major hive products of bees and is rich in flavonoids, which are known for their antioxidant activities. The aim of this study was to evaluate the hepatoprotective effects of the ethanolic extract of propolis (EEP) against experimental carbon tetrachloride (CCl 4)-induced liver toxicity in rats by means of biochemical indices. The animals were divided into 4 groups: GI= received mineral oil; GII= CCl 4(4mL/kg; Lp., single dose) treated; GIII= CCl4 (4mL/kg; i.p., single dose) treatment followed by ethanolic extract of propolis (100mg/kg) for gavage from the species Tetragonisca angustula, daily for 3 days and GIV= CCl4 (4mL/kg; i.p., single dose) treatment followed by ethanolic extract of propolis (100mg/kg) for gavage from the species Nannotrigonea testaceicornes, daily, for 3 days. The serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), cholesterol and triacylglycerols were estimated after 3 days. CCl 4 caused a maximum increase (p<0,01) above biochemical parameters. As compared to CCl4 group (GII), the EEP (GIII and GIV) showed reduction in cholesterol, triacylglycerol, ALT, AST and alkaline phosphatase activity in the serum. In conclusion, these data indicate that EEP improved the dyslipidaemia, moreover, significantly attenuated increases in serum ALT and AST activities in rats with liver damage induced by carbon tetrachloride.en
dc.description.affiliationDepartamento Química e Bioquímica Instituto de Biociências UNESP, 18618-000- Botucatu - SP
dc.description.affiliationDepartamento Microbiologie e Imunologia Instituto de Biociências UNESP, 18618-000- Botucatu - SP
dc.description.affiliationUnespDepartamento Química e Bioquímica Instituto de Biociências UNESP, 18618-000- Botucatu - SP
dc.description.affiliationUnespDepartamento Microbiologie e Imunologia Instituto de Biociências UNESP, 18618-000- Botucatu - SP
dc.format.extent85-89
dc.identifier.citationRevista de Ciencias Farmaceuticas, v. 25, n. 2, p. 85-89, 2004.
dc.identifier.issn0101-3793
dc.identifier.scopus2-s2.0-27444438566
dc.identifier.urihttp://hdl.handle.net/11449/68064
dc.language.isoeng
dc.relation.ispartofRevista de Ciencias Farmaceuticas
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectBiochemistry
dc.subjectCarbon tetrachloride
dc.subjectHepatotoxicity
dc.subjectPropolis
dc.subjectProtection
dc.subjectalanine aminotransferase
dc.subjectalcohol
dc.subjectalkaline phosphatase
dc.subjectcarbon tetrachloride
dc.subjectcholesterol
dc.subjectmineral oil
dc.subjectpropolis
dc.subjecttriacylglycerol
dc.subjectalanine aminotransferase blood level
dc.subjectalkaline phosphatase blood level
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectcontrolled study
dc.subjectdrug effect
dc.subjectdrug isolation
dc.subjectdyslipidemia
dc.subjectenzyme activity
dc.subjectfeeding
dc.subjectliver protection
dc.subjectliver toxicity
dc.subjectmale
dc.subjectmedicinal plant
dc.subjectnannotrigonea testaceicornes
dc.subjectnonhuman
dc.subjectrat
dc.subjecttetragonisca angustula
dc.subjecttriacylglycerol blood level
dc.titleEffect of Brazilian propolis on experimental hepatotoxicity in ratsen
dc.typeArtigo
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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