Short-term effects of α-melanocyte-stimulating hormone in three distinct melanin-pigmented cell types of Anura

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dc.contributor.authorZieri, Rodrigo
dc.contributor.authorFranco-Belussi, Lilian
dc.contributor.authorDE OLIVEIRA, Classius [UNESP]
dc.contributor.institutionLaboratório de Zoologia e Anatomia Animal Comparada
dc.contributor.institutionUniversidade Federal de Mato Grosso do Sul (UFMS)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2023-07-29T13:47:29Z
dc.date.available2023-07-29T13:47:29Z
dc.date.issued2023-01-01
dc.description.abstractEctothermic animals present melanin-containing cells in their integument and viscera. Besides cutaneous melanophores, amphibians have melanomacrophages in the hepatic parenchyma and melanocytes in the viscera, which are also present in their testicular stroma. The native melanocyte stimulating hormone (α-MSH) is the main hormone that modulates the color change in melanophores. However, we still know too little about how the α-MSH acts in vivo on visceral melanin-containing cells. In this study, we collected 30 adult males of Physalaemus nattereri (Anura, Leptodactylidae) to evaluate the short-term effects of α-MSH on melanophores, melanocytes and melanomacrophages under light microscopy. For this, we injected 0.05 ml of a single intraperitoneal dose containing 2.5x10-7 mmol/10g of α-MSH, diluted in ringer solution, in five experimental groups with five individuals each one. The different groups were analyzed after 1, 3, 6, 12 and 24h. The control group with five other individuals received only 0.05 ml of ringer solution. The skin pigmentation increased quickly after animals received the hormone α-MSH with the consequent darkening of the body (body darkness). Melanophores, melanocytes and melanomacrophages responded similarly to the test, with an increase in the area containing melanin. However, melanophores and melanomacrophages reached their darkest pigmentation in a shorter period of time in comparison to the testicular melanocytes, probably due to specific metabolic characteristics of each organ. Thus, we verified that the three types of cells, although present in different organs, are responsive to the native hormone α-MSH, which enables us to treat them as a pigmentary system.en
dc.description.affiliationInstituto Federal de Educação Ciência e Tecnologia de São Paulo/IFSP Laboratório de Zoologia e Anatomia Animal Comparada, Avenida C-Um, 250, SP
dc.description.affiliationUniversidade Federal de Mato Grosso do Sul/ UFMS Laboratório de Patologia Experimental (LAPEx) Instituto de Biociências s/n Universitário, MS
dc.description.affiliationUniversidade Estadual Paulista/IBILCE/UNESP Departamento de Biologia Laboratório de Anatomia Comparativa, Rua Cristóvão Colombo, 2265, SP
dc.description.affiliationUnespUniversidade Estadual Paulista/IBILCE/UNESP Departamento de Biologia Laboratório de Anatomia Comparativa, Rua Cristóvão Colombo, 2265, SP
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdCNPq: 473499/2010-0
dc.identifierhttp://dx.doi.org/10.1590/0001-3765202320211581
dc.identifier.citationAnais da Academia Brasileira de Ciencias, v. 95, n. 1, 2023.
dc.identifier.doi10.1590/0001-3765202320211581
dc.identifier.issn1678-2690
dc.identifier.issn0001-3765
dc.identifier.scopus2-s2.0-85150855819
dc.identifier.urihttp://hdl.handle.net/11449/248565
dc.language.isoeng
dc.relation.ispartofAnais da Academia Brasileira de Ciencias
dc.sourceScopus
dc.subjectmelanocytes
dc.subjectmelanomacrophages
dc.subjectmelanophores
dc.subjectPhysalaemus nattereri
dc.subjectα-MSH
dc.titleShort-term effects of α-melanocyte-stimulating hormone in three distinct melanin-pigmented cell types of Anuraen
dc.typeArtigo
unesp.author.orcid0000-0002-0945-7037[1]
unesp.author.orcid0000-0003-1938-8423[2]
unesp.author.orcid0000-0002-2029-7900[3]

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