Myeloperoxidase as inflammatory marker of periodontal disease: Experimental study in rats

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dc.contributor.authorGomes, Dbora A. S.
dc.contributor.authorPires, Juliana R.
dc.contributor.authorZuza, Elizangela P.
dc.contributor.authorMuscara, Marcelo N.
dc.contributor.authorHerrera, Bruno S.
dc.contributor.authorSpolidorio, Lus C.
dc.contributor.authorToledo, Benedicto E. C.
dc.contributor.authorSpolidorio, Denise M. P.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionEducational Foundation of Barretos
dc.date.accessioned2022-04-29T08:43:58Z
dc.date.available2022-04-29T08:43:58Z
dc.date.issued2009-11-09
dc.description.abstractRationale: Previous studies have used myeloperoxidase (MPO) as an inflammatory marker to estimate the accumulation of neutrophils in inflamed regions. Objective: The aim of this experimental study was to quantify the levels of MPO related to experimental periodontal disease in rats. Methods: Periodontal disease was induced in a group of rats using placement of a ligature around molar teeth. A group of rats without ligature placement served as a control. Measurements were made on the 3rd, 7th, 15 th and 30th day from baseline. Gingival tissues were taken for quantification of MPO levels by ELISA. Results: The rats with induced periodontal disease showed statistically higher MPO levels (p < 0.05) when compared to control rats. A significant increase in the levels of MPO released on days 7 and 30 was observed, with higher levels in the group with induced periodontitis. Conclusion: The levels of MPO were found to be higher in rats with induced periodontal disease, confirming the hypothesis that MPO may serve as an inflammatory marker for periodontitis.en
dc.description.affiliationDepartment of Diagnosis and Oral Surgery State University of São Paulo, Araraquara, São Paulo
dc.description.affiliationDepartment of Periodontics Educational Foundation of Barretos, Barretos, São Paulo
dc.description.affiliationDepartment of Pathology State University of São Paulo, Araraquara, São Paulo
dc.description.affiliationDepartment of Pharmacology University of São Paulo (USP), São Paulo
dc.format.extent117-122
dc.identifierhttp://dx.doi.org/10.1080/08820130802457503
dc.identifier.citationImmunological Investigations, v. 38, n. 2, p. 117-122, 2009.
dc.identifier.doi10.1080/08820130802457503
dc.identifier.issn0882-0139
dc.identifier.issn1532-4311
dc.identifier.scopus2-s2.0-65549118885
dc.identifier.urihttp://hdl.handle.net/11449/231198
dc.language.isoeng
dc.relation.ispartofImmunological Investigations
dc.sourceScopus
dc.subjectEnzymes
dc.subjectInflammation
dc.subjectPeriodontal diseases
dc.subjectPeroxidase
dc.titleMyeloperoxidase as inflammatory marker of periodontal disease: Experimental study in ratsen
dc.typeArtigo

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Artigos - Diagnóstico e Cirurgia - FOAR
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