Citral: A monoterpene with prophylactic and therapeutic anti-nociceptive effects in experimental models of acute and chronic pain

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dc.contributor.authorNishijima, Catarine M. [UNESP]
dc.contributor.authorGanev, Ellen G. [UNESP]
dc.contributor.authorMazzardo-Martins, Leidiane
dc.contributor.authorMartins, Daniel E.
dc.contributor.authorRocha, Lucia R. M. [UNESP]
dc.contributor.authorSantos, Adair R. S.
dc.contributor.authorHiruma-Lima, Clelia A. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de Santa Catarina (UFSC)
dc.date.accessioned2014-12-03T13:08:53Z
dc.date.available2014-12-03T13:08:53Z
dc.date.issued2014-08-05
dc.description.abstractCitral (3,7-dimethy1-2,6-octadienal) is an open-chain monoterpenoid present in the essential oils of several medicinal plants. The aim of this work was to evaluate the effects of orally administered citral in experimental models of acute and chronic nociception, inflammation, and gastric ulcers caused by nonsteroidal anti-inflammatory drugs (NSAIDs). Oral treatment with citral significantly inhibited the neurogenic and inflammatory pain responses induced by intra-plantar injection of formalin. Citral also had prophylactic and therapeutic anti-nociceptive effects against mechanical hyperalgesia in plantar incision surgery, chronic regional pain syndrome, and partial ligation of sciatic nerve models, without producing any significant motor dysfunction. In addition, citral markedly attenuated the pain response induced by intra-plantar injection of glutamate and phorbol 12-myristate 13-acetate (PMA, a protein kinase C activator), as well as by intrathecal (i.t.) injection of ionotropic and metabotropic glutamate receptor agonists (N-methyl-D-aspartic acid [NMDA] and 1-amino-1,3-dicarboxycyclopentane [trans-ACPD], respectively), substance P, and cytokine tumour necrosis factor-alpha. However, citral potentiated behaviours indicative of pain caused by i.t, but not intra-plantar, injection of a transient receptor potential vanilloid receptor type 1 (TRPV1) agonist. Finally, the anti-nociceptive action of citral was found to involve significant activation of the 5-HT2A serotonin receptor. The effect of citral was accompanied by a gastro-protective effect against NSAID-induced ulcers. Together, these results show the potential of citral as a new drug for the treatment of pain. (C) 2014 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Estadual Paulista, Biosci Inst, Dept Physiol, Nat Prod Lab, BR-18618970 Sao Paulo, Brazil
dc.description.affiliationUniv Fed Santa Catarina, Ctr Biol Sci, Dept Physiol Sci, Lab Neurobiol Pain & Inflammat, BR-88040900 Florianopolis, SC, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Biosci Inst, Dept Physiol, Nat Prod Lab, BR-18618970 Sao Paulo, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipFundacao de Amparo a Pesquisa e Inovacao do Estado de Santa Catarina (FAPESC), of Brazil
dc.format.extent16-25
dc.identifierhttp://dx.doi.org/10.1016/j.ejphar.2014.04.029
dc.identifier.citationEuropean Journal Of Pharmacology. Amsterdam: Elsevier Science Bv, v. 736, p. 16-25, 2014.
dc.identifier.doi10.1016/j.ejphar.2014.04.029
dc.identifier.issn0014-2999
dc.identifier.lattes3814504901386844
dc.identifier.orcid0000-0002-8645-3777
dc.identifier.urihttp://hdl.handle.net/11449/111669
dc.identifier.wosWOS:000338392900003
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofEuropean Journal of Pharmacology
dc.relation.ispartofjcr3.040
dc.relation.ispartofsjr1,057
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectCitralen
dc.subjectNeuropathic painen
dc.subjectChronic painen
dc.subjectPostoperative painen
dc.subjectChronic regional pain syndromeen
dc.subjectGastro-protective effecten
dc.titleCitral: A monoterpene with prophylactic and therapeutic anti-nociceptive effects in experimental models of acute and chronic painen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes3814504901386844[7]
unesp.author.orcid0000-0002-8645-3777[7]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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