Determination of 5-aminosalicylic acid in pharmaceutical formulations by square wave voltammetry at pencil graphite electrodes

Carregando...
Imagem de Miniatura

Data

2010-01-01

Título da Revista

ISSN da Revista

Título de Volume

Editor

Sociedade Brasileira de Química

Resumo

An analytical method for the determination of the anti-inflammatory drug 5-aminosalicylic acid (5-ASA) in pharmaceutical formulations using square wave voltammetry at pencil graphite electrodes was developed. After the optimization of the experimental conditions, calibration curves were obtained in the linear concentration range from 9.78 × 10-7 to 7.25 × 10-5 mol L-1 resulting in a limit of detection of 2.12 ± 0.05 x 10-8 mol L-1. Statistical tests showed that the concentrations of 5-ASA in commercial tablets and enemas obtained with the proposed voltammetric method agreed with HPLC values at a 95% confidence level.

Descrição

Palavras-chave

5-aminosalicylic acid, pharmaceutical formulations, pencil graphite electrode

Como citar

Química Nova. Sociedade Brasileira de Química, v. 33, n. 4, p. 964-967, 2010.