Transdentinal protective role of sodium ascorbate against the cytopathic effects of H2O2 released from bleaching agents

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dc.contributor.authorLima, Adriano Fonseca
dc.contributor.authorRosetti Lessa, Fernanda Campos
dc.contributor.authorGasparoto Mancini, Maria Nadir [UNESP]
dc.contributor.authorHebling, Josimeri [UNESP]
dc.contributor.authorde Souza Costa, Carlos Alberto [UNESP]
dc.contributor.authorMarchi, Giselle Maria
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2013-09-30T18:32:15Z
dc.date.accessioned2014-05-20T13:44:49Z
dc.date.available2013-09-30T18:32:15Z
dc.date.available2014-05-20T13:44:49Z
dc.date.issued2010-04-01
dc.description.abstractObjectives. The objectives of this study were to evaluate the transdentinal cytotoxicity of 10% and 16% carbamide peroxide gel (CP), as well as the ability of the antioxidant, 10% sodium ascorbate (SA), to protect the odontoblasts in culture.Study design. Human dentin discs of 0.5-mm thickness were obtained and were placed into artificial pulp chambers. MDPC-23 odontoblastlike cells were seeded on pulp surface of the discs and the following groups were established: G1-No Treatment (control), G2-10% SA/6hs, G3-10%/CP6hs, G4-10%SA/6hs+10%CP/6hs, G5-16%CP/6hs, and G6-10%SA/6hs+16%CP/6hs. The cell viability was measured by the MTT assay.Results. In groups where 16% CP was used, decreased cell viability was observed. Conversely, the application of 10% SA on the dentin discs, before the use of the CP, reduced the cytotoxic effects of these products on cells.Conclusions. The 16% CP cause a significant decrease in MDPC-23 cell viability and 10% SA was able to partially prevent the toxic effects of CP. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010; 109: e70-e76)en
dc.description.affiliationUniv São Paulo State, UNESP, Fac Odontol Araraquara, Dept Fisiol & Patol,Araraquara Sch Dent, BR-14801903 Araraquara, SP, Brazil
dc.description.affiliationUniv Estadual Campinas, Piracicaba Sch Dent, Dept Restorat Dent, Piracicaba, SP, Brazil
dc.description.affiliationUniv São Paulo State, UNESP, Sao Jose dos Campos Sch Dent, Dept Physiol Sci, Sao Jose Dos Campos, SP, Brazil
dc.description.affiliationUniv São Paulo State, UNESP, Dept Orthodont & Pediat Dent, Araraquara Sch Dent, BR-14801903 Araraquara, SP, Brazil
dc.description.affiliationUnespUniv São Paulo State, UNESP, Fac Odontol Araraquara, Dept Fisiol & Patol,Araraquara Sch Dent, BR-14801903 Araraquara, SP, Brazil
dc.description.affiliationUnespUniv São Paulo State, UNESP, Sao Jose dos Campos Sch Dent, Dept Physiol Sci, Sao Jose Dos Campos, SP, Brazil
dc.description.affiliationUnespUniv São Paulo State, UNESP, Dept Orthodont & Pediat Dent, Araraquara Sch Dent, BR-14801903 Araraquara, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 06-58780-8
dc.description.sponsorshipIdFAPESP: 08/05890-6
dc.description.sponsorshipIdCNPq: 476137/2006
dc.description.sponsorshipIdCNPq: 301029/2007-5
dc.format.extentE70-E76
dc.identifierhttp://dx.doi.org/10.1016/j.tripleo.2009.12.020
dc.identifier.citationOral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology. New York: Mosby-elsevier, v. 109, n. 4, p. E70-E76, 2010.
dc.identifier.doi10.1016/j.tripleo.2009.12.020
dc.identifier.issn1079-2104
dc.identifier.lattes4517484241515548
dc.identifier.urihttp://hdl.handle.net/11449/15722
dc.identifier.wosWOS:000275746200035
dc.language.isoeng
dc.publisherMosby-elsevier
dc.relation.ispartofOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleTransdentinal protective role of sodium ascorbate against the cytopathic effects of H2O2 released from bleaching agentsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderMosby-elsevier
unesp.author.lattes4517484241515548[5]
unesp.author.orcid0000-0002-0945-1305[6]
unesp.author.orcid0000-0002-1507-2264[1]
unesp.author.orcid0000-0002-7455-6867[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

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