5-HT1A receptors in the dorsal hippocampus mediate the anxiogenic effect induced by the stimulation of 5-HT neurons in the median raphe nucleus
dc.contributor.author | Santos, Lucinéia dos [UNESP] | |
dc.contributor.author | Andrade, Telma Gonçalves Carneiro Spera de [UNESP] | |
dc.contributor.author | Junior, Helio Zangrossi | |
dc.contributor.institution | Universidade de São Paulo (USP) | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.date.accessioned | 2014-05-20T13:22:11Z | |
dc.date.available | 2014-05-20T13:22:11Z | |
dc.date.issued | 2008-04-01 | |
dc.description.abstract | We evaluated the involvement of dorsal hippocampus (DH) 5-HT1A receptors in the mediation of the behavioral effects caused by the pharmacological manipulation of 5-HT neurons in the median raphe nucleus (MRN). To this end, we used the rat elevated T-maze test of anxiety. The results showed that intra-DH injection of the 5-HT1A/7 agonist 8-OH-DPAT facilitated inhibitory avoidance, an anxiogenic effect, without affecting escape. Microinjection of the 5-HT1A antagonist WAY-100635 was ineffective. In the elevated T-maze, inhibitory avoidance and escape have been related to generalized anxiety and panic disorders, respectively. Intra-MRN administration of the excitatory aminoacid kainic acid, which non-selectively stimulates 5-HT neurons in this brain area facilitated inhibitory avoidance and impaired escape performance, but also affected locomotion. Intra-MRN injection of WAY-100635, which has a disinhibitory effect on the activity of 5-HT neurons in this midbrain area, only facilitated inhibitory avoidance. Preadministration of WAY-100635 into the DH blocked the behavioral effect of intra-MRN injection of WAY-100635, but not of kainic acid. These results indicate that DH 5-HT1A receptors mediate the anxiogenic effect induced by the selective stimulation of 5-HT neurons in the MRN. (c) 2007 Elsevier B.V. and ECNP. All rights reserved. | en |
dc.description.affiliation | Univ São Paulo, Sch Med, Dept Pharmacol, BR-14049900 Ribeirao Preto, SP, Brazil | |
dc.description.affiliation | Univ São Paulo, FFCLRP, Dept Pharmacol & Educ, BR-14049900 Ribeirao Preto, SP, Brazil | |
dc.description.affiliation | UNESP, FCLA, Dept Biol Sci, BR-19806900 Assis, SP, Brazil | |
dc.description.affiliationUnesp | UNESP, FCLA, Dept Biol Sci, BR-19806900 Assis, SP, Brazil | |
dc.format.extent | 286-294 | |
dc.identifier | http://dx.doi.org/10.1016/j.euroneuro.2007.07.007 | |
dc.identifier.citation | European Neuropsychopharmacology. Amsterdam: Elsevier B.V., v. 18, n. 4, p. 286-294, 2008. | |
dc.identifier.doi | 10.1016/j.euroneuro.2007.07.007 | |
dc.identifier.issn | 0924-977X | |
dc.identifier.lattes | 2620573504503756 | |
dc.identifier.uri | http://hdl.handle.net/11449/6485 | |
dc.identifier.wos | WOS:000254250700007 | |
dc.language.iso | eng | |
dc.publisher | Elsevier B.V. | |
dc.relation.ispartof | European Neuropsychopharmacology | |
dc.relation.ispartofjcr | 4.129 | |
dc.rights.accessRights | Acesso restrito | |
dc.source | Web of Science | |
dc.subject | median raphe nucleus | en |
dc.subject | dorsal hippocampus | en |
dc.subject | 5-HT1A receptors | en |
dc.subject | serotonin | en |
dc.subject | generalized anxiety and panic | en |
dc.title | 5-HT1A receptors in the dorsal hippocampus mediate the anxiogenic effect induced by the stimulation of 5-HT neurons in the median raphe nucleus | en |
dc.type | Artigo | |
dcterms.license | http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy | |
dcterms.rightsHolder | Elsevier B.V. | |
unesp.author.lattes | 2620573504503756[1] | |
unesp.author.orcid | 0000-0002-7918-8776[2] | |
unesp.author.orcid | 0000-0002-2826-2622[1] | |
unesp.campus | Universidade Estadual Paulista (Unesp), Faculdade de Ciências e Letras, Assis | pt |
unesp.department | Ciências Biológicas - FCLAS | pt |
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