5-HT1A receptors in the dorsal hippocampus mediate the anxiogenic effect induced by the stimulation of 5-HT neurons in the median raphe nucleus

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dc.contributor.authorSantos, Lucinéia dos [UNESP]
dc.contributor.authorAndrade, Telma Gonçalves Carneiro Spera de [UNESP]
dc.contributor.authorJunior, Helio Zangrossi
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:22:11Z
dc.date.available2014-05-20T13:22:11Z
dc.date.issued2008-04-01
dc.description.abstractWe evaluated the involvement of dorsal hippocampus (DH) 5-HT1A receptors in the mediation of the behavioral effects caused by the pharmacological manipulation of 5-HT neurons in the median raphe nucleus (MRN). To this end, we used the rat elevated T-maze test of anxiety. The results showed that intra-DH injection of the 5-HT1A/7 agonist 8-OH-DPAT facilitated inhibitory avoidance, an anxiogenic effect, without affecting escape. Microinjection of the 5-HT1A antagonist WAY-100635 was ineffective. In the elevated T-maze, inhibitory avoidance and escape have been related to generalized anxiety and panic disorders, respectively. Intra-MRN administration of the excitatory aminoacid kainic acid, which non-selectively stimulates 5-HT neurons in this brain area facilitated inhibitory avoidance and impaired escape performance, but also affected locomotion. Intra-MRN injection of WAY-100635, which has a disinhibitory effect on the activity of 5-HT neurons in this midbrain area, only facilitated inhibitory avoidance. Preadministration of WAY-100635 into the DH blocked the behavioral effect of intra-MRN injection of WAY-100635, but not of kainic acid. These results indicate that DH 5-HT1A receptors mediate the anxiogenic effect induced by the selective stimulation of 5-HT neurons in the MRN. (c) 2007 Elsevier B.V. and ECNP. All rights reserved.en
dc.description.affiliationUniv São Paulo, Sch Med, Dept Pharmacol, BR-14049900 Ribeirao Preto, SP, Brazil
dc.description.affiliationUniv São Paulo, FFCLRP, Dept Pharmacol & Educ, BR-14049900 Ribeirao Preto, SP, Brazil
dc.description.affiliationUNESP, FCLA, Dept Biol Sci, BR-19806900 Assis, SP, Brazil
dc.description.affiliationUnespUNESP, FCLA, Dept Biol Sci, BR-19806900 Assis, SP, Brazil
dc.format.extent286-294
dc.identifierhttp://dx.doi.org/10.1016/j.euroneuro.2007.07.007
dc.identifier.citationEuropean Neuropsychopharmacology. Amsterdam: Elsevier B.V., v. 18, n. 4, p. 286-294, 2008.
dc.identifier.doi10.1016/j.euroneuro.2007.07.007
dc.identifier.issn0924-977X
dc.identifier.lattes2620573504503756
dc.identifier.urihttp://hdl.handle.net/11449/6485
dc.identifier.wosWOS:000254250700007
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofEuropean Neuropsychopharmacology
dc.relation.ispartofjcr4.129
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectmedian raphe nucleusen
dc.subjectdorsal hippocampusen
dc.subject5-HT1A receptorsen
dc.subjectserotoninen
dc.subjectgeneralized anxiety and panicen
dc.title5-HT1A receptors in the dorsal hippocampus mediate the anxiogenic effect induced by the stimulation of 5-HT neurons in the median raphe nucleusen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes2620573504503756[1]
unesp.author.orcid0000-0002-7918-8776[2]
unesp.author.orcid0000-0002-2826-2622[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências e Letras, Assispt
unesp.departmentCiências Biológicas - FCLASpt

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