Current perspectives on defining and mitigating frailty in relation to critical illness

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dc.contributor.authorCosta, N. A.
dc.contributor.authorMinicucci, M. F. [UNESP]
dc.contributor.authorPereira, A. G. [UNESP]
dc.contributor.authorde Paiva, S. A.R. [UNESP]
dc.contributor.authorOkoshi, M. P. [UNESP]
dc.contributor.authorPolegato, B. F. [UNESP]
dc.contributor.authorZornoff, L. A.M. [UNESP]
dc.contributor.authorVillas Boas, P. J.F. [UNESP]
dc.contributor.authorAtherton, P. J.
dc.contributor.authorPhillips, B. E.
dc.contributor.authorBanerjee, J.
dc.contributor.authorGordon, A. L.
dc.contributor.authorAzevedo, P. S. [UNESP]
dc.contributor.institutionUniversidade Federal de Goiás (UFG)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversity of Nottingham
dc.contributor.institutionUniversity of Leicester
dc.date.accessioned2022-04-29T08:35:06Z
dc.date.available2022-04-29T08:35:06Z
dc.date.issued2021-11-01
dc.description.abstractUp to half of ICU survivors, many of whom were premorbidly well, will have residual functional and/or cognitive impairment and be vulnerable to future health problems. Frailty describes vulnerability to poor resolution of homeostasis after a stressor event but it is not clear whether the vulnerability seen after ICU correlates with clinical measures of frailty. In clinical practice, the scales most commonly used in critically ill patients are based on the assessment of severity and survival. Identification and monitoring of frailty in the ICU may be an alternative or complimentary approach, particularly if it helps explain vulnerability during the recovery and rehabilitation period. The purpose of this review is to discuss the use of tools to assess frailty status in the critically ill, and consider their importance in clinical practice. Amongst these, we consider biomarkers with potential to identify patients at greater or lesser risk of developing post-ICU vulnerability.en
dc.description.affiliationFaculty of Nutrition Univ Federal de Goiás (UFG)
dc.description.affiliationDepartment of Internal Medicine Botucatu Medical School UNESP – Univ Estadual Paulista
dc.description.affiliationMedical Research Council-Versus Arthritis Centre for Musculoskeletal Ageing Research and National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre University of Nottingham
dc.description.affiliationGeriatric Emergency Medicine University Hospitals of Leicester School of Health Science University of Leicester
dc.description.affiliationUnespDepartment of Internal Medicine Botucatu Medical School UNESP – Univ Estadual Paulista
dc.format.extent5430-5437
dc.identifierhttp://dx.doi.org/10.1016/j.clnu.2021.09.017
dc.identifier.citationClinical Nutrition, v. 40, n. 11, p. 5430-5437, 2021.
dc.identifier.doi10.1016/j.clnu.2021.09.017
dc.identifier.issn1532-1983
dc.identifier.issn0261-5614
dc.identifier.scopus2-s2.0-85116864710
dc.identifier.urihttp://hdl.handle.net/11449/229685
dc.language.isoeng
dc.relation.ispartofClinical Nutrition
dc.sourceScopus
dc.subjectCritical illness
dc.subjectFrailty
dc.subjectGeriatric rehabilitation
dc.subjectICU weakness
dc.subjectNutrition
dc.titleCurrent perspectives on defining and mitigating frailty in relation to critical illnessen
dc.typeResenha
unesp.author.orcid0000-0001-8159-1209[1]
unesp.author.orcid0000-0002-5980-4367[2]
unesp.author.orcid0000-0002-2875-9532[6]
unesp.author.orcid0000-0001-9876-3222[8]
unesp.author.orcid0000-0002-5843-6232[13]

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