Mapping the BDA20 Gene to BTAX
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Data
2008-01-01
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Coorientador
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Editor
Karger
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Trabalho apresentado em evento
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Acesso aberto
Resumo
The lipocalin family is a large group of proteins that exhibits great structural and functional variation both within and among species, including a significant number of animal-derived aeroallergens, such as the bovine BDA20 (major cow dander allergen). This protein is classified as an occupational allergen causing asthma and other work-related allergic disorders among dairy farmers. Using a somatic cell panel the BDA20 gene was assigned to the bovine X chromosome (BTAX) with a significant concordant value of 97% to the previously mapped reference marker MAF45. A radiation hybrid (RH) mapping approach confirmed the assignment of BDA20 to BTAX. Two-point LOD scores showed that BDA20 is linked to XBM451 with a LOD score of 22.1 for a 0 value of 0.03.
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Animal Genomics For Animal Health. Basel: Karger, v. 132, p. 359-361, 2008.