Evidence Linking PPARG Genetic Variants with Periodontitis and Type 2 Diabetes Mellitus in a Brazilian Population

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dc.contributor.authorCirelli, Thamiris [UNESP]
dc.contributor.authorNicchio, Ingra G. [UNESP]
dc.contributor.authorBussaneli, Diego G. [UNESP]
dc.contributor.authorSilva, Bárbara R. [UNESP]
dc.contributor.authorNepomuceno, Rafael [UNESP]
dc.contributor.authorOrrico, Silvana R. P. [UNESP]
dc.contributor.authorCirelli, Joni A. [UNESP]
dc.contributor.authorTheodoro, Letícia H. [UNESP]
dc.contributor.authorBarros, Silvana P.
dc.contributor.authorScarel-Caminaga, Raquel M. [UNESP]
dc.contributor.institutionUniversity Center—UNIFAE
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUnion of the Colleges of the Great Lakes—UNILAGO
dc.contributor.institutionUniversity of North Carolina at Chapel Hill—UNC
dc.date.accessioned2023-07-29T13:51:33Z
dc.date.available2023-07-29T13:51:33Z
dc.date.issued2023-04-01
dc.description.abstractThe peroxisome proliferator-activated receptor gamma (PPARG) gene encodes a transcription factor involved in the regulation of complex metabolic and inflammatory diseases. We investigated whether single nucleotide polymorphisms (SNPs) and haplotypes of the PPARG gene could contribute with susceptibility to develop periodontitis alone or together with type 2 diabetes mellitus (T2DM). Moreover, we evaluated the gene–phenotype association by assessing the subjects’ biochemical and periodontal parameters, and the expression of PPARG and other immune response–related genes. We examined 345 subjects with a healthy periodontium and without T2DM, 349 subjects with moderate or severe periodontitis but without T2DM, and 202 subjects with moderate or severe periodontitis and T2DM. PPARG SNPs rs12495364, rs1801282, rs1373640, and rs1151999 were investigated. Multiple logistic regressions adjusted for age, sex, and smoking status showed that individuals carrying rs1151999-GG had a 64% lower chance of developing periodontitis together with T2DM. The CCGT haplotype increased the risk of developing periodontitis together with T2DM. The rs1151999-GG and rs12495364-TC were associated with reduced risk of obesity, periodontitis, elevated triglycerides, and elevated glycated hemoglobin, but there was no association with gene expression. Polymorphisms of the PPARG gene were associated with developing periodontitis together with T2DM, and with obesity, lipid, glycemic, and periodontal characteristics.en
dc.description.affiliationDepartment of Dentistry School of Dentistry University Center—UNIFAE, SP
dc.description.affiliationDepartment of Diagnosis and Surgery School of Dentistry at Araraquara São Paulo State University—UNESP, SP
dc.description.affiliationDepartment of Morphology Genetics Orthodontics and Pediatric Dentistry School of Dentistry at Araraquara São Paulo State University—UNESP, SP
dc.description.affiliationAdvanced Research Center in Medicine Union of the Colleges of the Great Lakes—UNILAGO, SP
dc.description.affiliationDepartment of Diagnosis and Surgery School of Dentistry at Araçatuba São Paulo State University—UNESP, SP
dc.description.affiliationDepartment of Periodontology School of Dentistry University of North Carolina at Chapel Hill—UNC
dc.description.affiliationUnespDepartment of Diagnosis and Surgery School of Dentistry at Araraquara São Paulo State University—UNESP, SP
dc.description.affiliationUnespDepartment of Morphology Genetics Orthodontics and Pediatric Dentistry School of Dentistry at Araraquara São Paulo State University—UNESP, SP
dc.description.affiliationUnespDepartment of Diagnosis and Surgery School of Dentistry at Araçatuba São Paulo State University—UNESP, SP
dc.identifierhttp://dx.doi.org/10.3390/ijms24076760
dc.identifier.citationInternational Journal of Molecular Sciences, v. 24, n. 7, 2023.
dc.identifier.doi10.3390/ijms24076760
dc.identifier.issn1422-0067
dc.identifier.issn1661-6596
dc.identifier.scopus2-s2.0-85152774876
dc.identifier.urihttp://hdl.handle.net/11449/248709
dc.language.isoeng
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.sourceScopus
dc.subjectdyslipidemias
dc.subjectobesity
dc.subjectperiodontitis
dc.subjectperoxisome proliferator-activated receptors
dc.subjectsingle nucleotide polymorphisms
dc.subjecttype 2 diabetes mellitus
dc.titleEvidence Linking PPARG Genetic Variants with Periodontitis and Type 2 Diabetes Mellitus in a Brazilian Populationen
dc.typeArtigo
unesp.author.orcid0000-0001-9078-7385[3]
unesp.author.orcid0000-0002-3120-0617[5]
unesp.author.orcid0000-0003-2685-8526[6]
unesp.author.orcid0000-0002-7082-9290[7]

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Artigos - Diagnóstico e Cirurgia - FOAR
Artigos - Clínica Infantil - FOAR