Concentration of Fibroblasts in the Vocal Fold of Elderly

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dc.contributor.authorCarneiro, Neemias S. [UNESP]
dc.contributor.authorPessin, Adriana B.B. [UNESP]
dc.contributor.authorRodrigues, Sergio A. [UNESP]
dc.contributor.authorPellizon, Claudia H. [UNESP]
dc.contributor.authorXavier, Claudia M. [UNESP]
dc.contributor.authorMartins, Regina H.G. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2023-07-29T13:30:06Z
dc.date.available2023-07-29T13:30:06Z
dc.date.issued2022-01-01
dc.description.abstractObjective: To study the concentration of fibroblasts in the vocal folds of elderly people. Material and Methods: The vocal folds of 13 cadavers were removed and divided into two age groups: Control group: n-5, 18-40 years; Elderly group: n-8, ≥75 years). The vocal folds were dissected and prepared for immunohistochemical analysis using the SA100 antibody to fibroblasts. The sites analyzed were maculae flavae and medial (or vibrating) portion of the vocal folds. The AVsoft program was used to count the cells. Results: A higher concentration of fibroblasts was identified in the maculae flavae of the larynx of young adults and in the medial portion of the vocal folds of the elderly. However, these results did not determine statistically significant differences, allowing us to conclude that there was no effect of age on the concentration of fibroblasts in the vocal folds. Conclusion: In the larynx of the elderly, the fibroblast population remains similar to the young adults, both in the maculae flavae and in the body of the vocal folds, possibly being responsible for the constant production of fibrous matrix in the lamina propria. Functional changes in these cells are probably more marked than quantitative ones.en
dc.description.affiliationBotucatu Medical School Unesp
dc.description.affiliationSpeech Pathologist. Botucatu Medical School Unesp Botucatu
dc.description.affiliationBiostatistician. Department of Biostatistics Biosciences Institute Unesp Botucatu
dc.description.affiliationBiosciences Institute Unesp Botucatu
dc.description.affiliationHead and Neck Surgery Department Botucatu Medical School Unesp
dc.description.affiliationUnespBotucatu Medical School Unesp
dc.description.affiliationUnespSpeech Pathologist. Botucatu Medical School Unesp Botucatu
dc.description.affiliationUnespBiostatistician. Department of Biostatistics Biosciences Institute Unesp Botucatu
dc.description.affiliationUnespBiosciences Institute Unesp Botucatu
dc.description.affiliationUnespHead and Neck Surgery Department Botucatu Medical School Unesp
dc.identifierhttp://dx.doi.org/10.1016/j.jvoice.2022.10.017
dc.identifier.citationJournal of Voice.
dc.identifier.doi10.1016/j.jvoice.2022.10.017
dc.identifier.issn1873-4588
dc.identifier.issn0892-1997
dc.identifier.scopus2-s2.0-85142515270
dc.identifier.urihttp://hdl.handle.net/11449/247940
dc.language.isoeng
dc.relation.ispartofJournal of Voice
dc.sourceScopus
dc.subjectAging voice
dc.subjectFibroblasts
dc.subjectImmunohistchemical
dc.subjectPresbyphonia
dc.titleConcentration of Fibroblasts in the Vocal Fold of Elderlyen
dc.typeArtigo
unesp.author.orcid0000-0002-2091-2141[3]
unesp.author.orcid0000-0003-0772-1962[6]

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Artigos - Bioestatística - IBB
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