Evaluation of biochemical and redox parameters in rats fed with corn grown in soil amended with urban sewage sludge

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dc.contributor.authorGrotto, Denise
dc.contributor.authorCarneiro, Maria Fernanda Hornos
dc.contributor.authorSauer, Elisa
dc.contributor.authorGarcia, Solange Cristina
dc.contributor.authorde Melo, Wanderley José [UNESP]
dc.contributor.authorBarbosa, Fernando
dc.contributor.institutionUniversidade de Sorocaba
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal do Rio Grande do Sul (UFRGS)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:30:32Z
dc.date.available2014-05-27T11:30:32Z
dc.date.issued2013-09-01
dc.description.abstractThe increased production of urban sewage sludge requires alternative methods for final disposal. A very promising choice is the use of sewage sludge as a fertilizer in agriculture, since it is rich in organic matter, macro and micronutrients. However, urban sewage sludge may contain toxic substances that may cause deleterious effects on the biota, water and soil, and consequently on humans. There is a lack of studies evaluating how safe the consumption of food cultivated in soils containing urban sewage sludge is. Thus, the aim of this paper was to evaluate biochemical and redox parameters in rats fed with corn produced in a soil treated with urban sewage sludge for a long term. For these experiments, maize plants were grown in soil amended with sewage sludge (rates of 5, 10 and 20. t/ha) or not (control). Four different diets were prepared with the corn grains produced in the field experiment, and rats were fed with these diets for 1, 2, 4, 8 and 12 weeks. Biochemical parameters (glucose, total cholesterol and fractions, triglycerides, aspartate aminotransferase and alanine aminotransferase) as well the redox state biomarkers such as reduced glutathione (GSH), malondialdehyde (MDA), catalase, glutathione peroxidase and butyrylcholinesterase (BuChE) were assessed. Our results show no differences in the biomarkers over 1 or 2 weeks. However, at 4 weeks BuChE activity was inhibited in rats fed with corn grown in soil amended with sewage sludge (5, 10 and 20. t/ha), while MDA levels increased. Furthermore, prolonged exposure to corn cultivated in the highest amount per hectare of sewage sludge (8 and 12 weeks) was associated with an increase in MDA levels and a decrease in GSH levels, respectively. Our findings add new evidence of the risks of consuming food grown with urban sewage sludge. However, considering that the amount and type of toxic substances present in urban sewage sludge varies considerably among different sampling areas, further studies are needed to evaluate sludge samples collected from different sources and/or undergoing different types of treatment. © 2013 Elsevier Inc.en
dc.description.affiliationPrograma de Pós-Graduação em Ciências Farmacêuticas Universidade de Sorocaba, CEP 18023-000, Sorocaba, São Paulo
dc.description.affiliationFaculdade de Ciências Farmacêuticas de Ribeirão Preto Universidade de São Paulo Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, CEP 14040-903, Ribeirão Preto, São Paulo
dc.description.affiliationUniversidade Federal do Rio Grande do Sul Departamento de Análises Clínicas, CEP 90610-000, Porto Alegre, Rio Grande do Sul
dc.description.affiliationFaculdade de Ciências Agrárias e Veterinárias UNESP, Universidade Federal Paulista Departamento de Tecnologia, CEP 14884-900, Jaboticabal, São Paulo
dc.description.affiliationUnespFaculdade de Ciências Agrárias e Veterinárias UNESP, Universidade Federal Paulista Departamento de Tecnologia, CEP 14884-900, Jaboticabal, São Paulo
dc.format.extent188-194
dc.identifierhttp://dx.doi.org/10.1016/j.ecoenv.2013.05.038
dc.identifier.citationEcotoxicology and Environmental Safety, v. 95, p. 188-194.
dc.identifier.doi10.1016/j.ecoenv.2013.05.038
dc.identifier.issn0147-6513
dc.identifier.issn1090-2414
dc.identifier.scopus2-s2.0-84880327736
dc.identifier.urihttp://hdl.handle.net/11449/76400
dc.identifier.wosWOS:000322286400025
dc.language.isoeng
dc.relation.ispartofEcotoxicology and Environmental Safety
dc.relation.ispartofjcr3.974
dc.relation.ispartofsjr1,201
dc.relation.ispartofsjr1,201
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectBiochemical parameters
dc.subjectFood safety
dc.subjectOxidative stress
dc.subjectRisk assessment
dc.subjectUrban sewage sludge
dc.subjectalanine aminotransferase
dc.subjectarsenic
dc.subjectaspartate aminotransferase
dc.subjectbarium
dc.subjectcadmium
dc.subjectcatalase
dc.subjectcholesterol
dc.subjectcholesterol derivative
dc.subjectcholinesterase
dc.subjectchromium
dc.subjectcopper
dc.subjectglucose
dc.subjectglutathione
dc.subjectglutathione peroxidase
dc.subjectmalonaldehyde
dc.subjectmercury
dc.subjectmolybdenum
dc.subjectnickel
dc.subjectselenium
dc.subjecttriacylglycerol
dc.subjectzinc
dc.subjectbiochemical composition
dc.subjectbiomarker
dc.subjectenzyme activity
dc.subjectfertilizer
dc.subjectfood safety
dc.subjectmaize
dc.subjectredox conditions
dc.subjectrisk assessment
dc.subjectrodent
dc.subjectsewage
dc.subjectsludge
dc.subjectsoil amendment
dc.subjectanimal experiment
dc.subjectanimal food
dc.subjectanimal model
dc.subjectconcentration (parameters)
dc.subjectcontrolled study
dc.subjectenzyme inhibition
dc.subjectevaluation research
dc.subjectfield study
dc.subjectfood contamination
dc.subjectgrain
dc.subjectlong term exposure
dc.subjectmale
dc.subjectnonhuman
dc.subjectoxidation reduction state
dc.subjectplant growth
dc.subjectrat
dc.subjectsoil pollution
dc.subjecttoxicity testing
dc.subjecturban area
dc.subjecturban sewage sludge
dc.subjectRattus
dc.subjectZea mays
dc.titleEvaluation of biochemical and redox parameters in rats fed with corn grown in soil amended with urban sewage sludgeen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
unesp.author.orcid0000-0003-3752-5751[4]
unesp.author.orcid0000-0002-2498-0619[6]
unesp.author.orcid0000-0001-7041-6923[2]
unesp.author.orcid0000-0003-2683-0347[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Agrárias e Veterinárias, Jaboticabalpt

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