Estudio ultraestructural del diafragma desnervado en ratas

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dc.contributor.authorTorrejais, M. M.
dc.contributor.authorSoares, J. C. [UNESP]
dc.contributor.authorMatheus, S. M.M. [UNESP]
dc.contributor.authorMello, J. M.
dc.contributor.authorFrancia-Farje, L. A.D.
dc.contributor.authorJeronimo, L. C.
dc.contributor.authorVicente, E. J.D.
dc.contributor.institutionUNIOESTE
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade Estadual de Maringá (UEM)
dc.contributor.institutionFIB
dc.contributor.institutionUFJF
dc.date.accessioned2022-04-29T07:12:44Z
dc.date.available2022-04-29T07:12:44Z
dc.date.issued2013-12-03
dc.description.abstractThe structural alterations that occur in the muscle fibers of denervated rat diaphragms were studied. Fifteen adult male albino rats (Rattus norvegicus) with a mean weight of 200 g and about 60 days of age were used. Chronically denervated diaphragms were obtained and the animals were sacrificed after 4, 8 and 12 weeks of denervation. The left antimere of the diaphragm was denervated by sectioning of the phrenic nerve and the right antimere served as control. Each antimere was divided into fragments, which were used for analysis transmission electron microscopy. During the initial phase of denervation (4 weeks), ultrastructural muscle modifications appeared in scattered fibers and in foci along these fibers. Muscle fibers with foci of less dense and loosely arranged myofibrils, disorganized Z line, displaced T tubules, and central nucleus exhibiting reentrances and fragmented aspect were observed. After 8 weeks, formation of large aggregates of small elongated mitochondria showing altered cristae, matrix inclusions and increased electron density was noted. At 12 weeks of denervation the alterations were found to be more drastic. Nuclei with internal deposits of myofibrillar or amorphous material were observed. In these fibers, vacuoles harbored enormous myeloid structures in the subsarcolemmal or intermyofibrillar region.en
dc.description.affiliationMedical and Pharmaceutic Sciences Center UNIOESTE, Cascavel, PR
dc.description.affiliationDepartment of Anatomy Biosciences Institute UNESP, Botucatu, SP
dc.description.affiliationDepartment of Morphologic Sciences UEM, Maringá,PR
dc.description.affiliationFIB, Bauru, SP
dc.description.affiliationMaster of Bioscience and Health UNIOESTE, Cascavel, PR
dc.description.affiliationDepartment of Physiotherapy UFJF, Juiz de Fora, MG
dc.description.affiliationUnespDepartment of Anatomy Biosciences Institute UNESP, Botucatu, SP
dc.format.extent925-931
dc.identifierhttp://dx.doi.org/10.4067/S0717-95022013000300025
dc.identifier.citationInternational Journal of Morphology, v. 31, n. 3, p. 925-931, 2013.
dc.identifier.doi10.4067/S0717-95022013000300025
dc.identifier.issn0717-9367
dc.identifier.issn0717-9502
dc.identifier.scopus2-s2.0-84888408970
dc.identifier.urihttp://hdl.handle.net/11449/227330
dc.language.isoeng
dc.language.isospa
dc.relation.ispartofInternational Journal of Morphology
dc.sourceScopus
dc.subjectDenervation
dc.subjectDiaphragm
dc.subjectMuscle fiber
dc.subjectRat
dc.subjectUltrastructural
dc.titleEstudio ultraestructural del diafragma desnervado en ratases
dc.title.alternativeUltrastructural study of the denervated diaphragm in ratsen
dc.typeArtigo

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Artigos - Anatomia - IBB