Intra-uterine diazepam exposure decreases the number of catecholaminergic and serotoninergic neurons of neonate rats

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dc.contributor.authorda Silva Junior, Carlos Aparecido [UNESP]
dc.contributor.authorMarques, Danuzia A.
dc.contributor.authorPatrone, Luís Gustavo A. [UNESP]
dc.contributor.authorBiancardi, Vivian
dc.contributor.authorBícego, Kênia C. [UNESP]
dc.contributor.authorGargaglioni, Luciane H. [UNESP]
dc.contributor.institutionWilliam & Mary
dc.contributor.institutionUniversité Laval
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversity of Alberta
dc.date.accessioned2023-07-29T13:35:10Z
dc.date.available2023-07-29T13:35:10Z
dc.date.issued2023-01-31
dc.description.abstractBenzodiazepines, such as diazepam (DZP), are used to treat anxiety disorders, and are prescribed to pregnant woman for therapeutic purposes. Concerns regarding their consequences on postnatal development rise as they cross the placenta and interact with the embryo. Occurrence of malformation and behavioral syndromes have been reported for different ages, but little is known about their effects on the brain after exposure during intrauterine life. Thus, we sought to evaluate the effects of intrauterine exposure to DZP on the number of brainstem's catecholaminergic and serotonergic neurons, implicated in respiratory control, in male and female rats on postnatal (P) day 12–13, using immunofluorescence labeling for tyrosine–hydroxylase (TH) and serotonin (5–HT). We observed a reduction in the number of catecholaminergic neurons for males and females. Special attention is given to the reduction in the density of neurons in the A6 region, involved in ventilatory responses to CO2. Interestingly, only males showed a reduction in the number of serotonergic neurons, while females were not affected. These findings suggest that in utero exposure to DZP results in deleterious neuroanatomical effects on P12–13 rats and raises a note of concern for women clinicians to make more informed choices about the use of anxiolytic treatments during gestation.en
dc.description.affiliationDepartment of Applied Science William & Mary
dc.description.affiliationDepartment of Pediatrics Québec Heart and Lung Institute Université Laval
dc.description.affiliationDepartment of Animal Morphology and Physiology FCAV – UNESP – São Paulo State University, SP
dc.description.affiliationDepartment of Physiology Faculty of Medicine and Dentistry University of Alberta
dc.description.affiliationUnespDepartment of Animal Morphology and Physiology FCAV – UNESP – São Paulo State University, SP
dc.identifierhttp://dx.doi.org/10.1016/j.neulet.2022.137014
dc.identifier.citationNeuroscience Letters, v. 795.
dc.identifier.doi10.1016/j.neulet.2022.137014
dc.identifier.issn1872-7972
dc.identifier.issn0304-3940
dc.identifier.scopus2-s2.0-85145384410
dc.identifier.urihttp://hdl.handle.net/11449/248125
dc.language.isoeng
dc.relation.ispartofNeuroscience Letters
dc.sourceScopus
dc.subjectBenzodiazepine
dc.subjectBreathing
dc.subjectCatecholamine
dc.subjectCritical period
dc.subjectGABA
dc.subjectSerotonin
dc.titleIntra-uterine diazepam exposure decreases the number of catecholaminergic and serotoninergic neurons of neonate ratsen
dc.typeArtigo
unesp.author.orcid0000-0003-4097-5286[6]

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