Immunological evaluation of young unvaccinated patients with Turner syndrome after COVID-19

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dc.contributor.authorde Castro, Mateus V.
dc.contributor.authorSilva, Monize V.R.
dc.contributor.authorOliveira, Luana de M.
dc.contributor.authorGozzi-Silva, Sarah C.
dc.contributor.authorNaslavsky, Michel S.
dc.contributor.authorScliar, Marilia O.
dc.contributor.authorMagalhães, Monize L.
dc.contributor.authorda Rocha, Katia M.
dc.contributor.authorNunes, Kelly
dc.contributor.authorCastelli, Erick C. [UNESP]
dc.contributor.authorMagawa, Jhosiene Y.
dc.contributor.authorSantos, Keity S.
dc.contributor.authorCunha-Neto, Edecio
dc.contributor.authorSato, Maria N.
dc.contributor.authorZatz, Mayana
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionInstituto de Investigação em Imunologia - Instituto Nacional de Ciências e Tecnologia-iii-INCT
dc.date.accessioned2023-07-29T14:00:49Z
dc.date.available2023-07-29T14:00:49Z
dc.date.issued2023-04-01
dc.description.abstractObjectives: The X-chromosome contains the largest number of immune-related genes, which play a major role in COVID-19 symptomatology and susceptibility. Here, we had a unique opportunity to investigate, for the first time, COVID-19 outcomes in six unvaccinated young Brazilian patients with Turner syndrome (TS; 45, X0), including one case of critical illness in a child aged 10 years, to evaluate their immune response according to their genetic profile. Methods: A serological analysis of humoral immune response against SARS-CoV-2, phenotypic characterization of antiviral responses in peripheral blood mononuclear cells after stimuli, and the production of cytotoxic cytokines of T lymphocytes and natural killer cells were performed in blood samples collected from the patients with TS during the convalescence period. Whole exome sequencing was also performed. Results: Our volunteers with TS showed a delayed or insufficient humoral immune response to SARS-CoV-2 (particularly immunoglobulin G) and a decrease in interferon-γ production by cluster of differentiation (CD)4+ and CD8+ T lymphocytes after stimulation with toll-like receptors 7/8 agonists. In contrast, we observed a higher cytotoxic activity in the volunteers with TS than the volunteers without TS after phorbol myristate acetate/ionomycin stimulation, particularly granzyme B and perforin by CD8+ and natural killer cells. Interestingly, two volunteers with TS carry rare genetic variants in genes that regulate type I and III interferon immunity. Conclusion: Following previous reports in the literature for other conditions, our data showed that patients with TS may have an impaired immune response against SARS-CoV-2. Furthermore, other medical conditions associated with TS could make them more vulnerable to COVID-19.en
dc.description.affiliationHuman Genome and Stem Cell Research Center University of São Paulo, São Paulo
dc.description.affiliationLaboratório de Investigação em Dermatologia e Imunodeficiências LIM 56 Instituto de Medicina Tropical Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo
dc.description.affiliationDepartamento de Dermatologia Faculdade de Medicina da Universidade de São Paulo, São Paulo
dc.description.affiliationDepartamento de Imunologia Instituto de Ciências Biomédicas Universidade de São Paulo, São Paulo
dc.description.affiliationDepartment of Genetics and Evolutionary Biology Biosciences Institute University of São Paulo, São Paulo
dc.description.affiliationSchool of Medicine Universidade Estadual Paulista
dc.description.affiliationLaboratório de Imunologia Instituto do Coração (InCor) LIM19 Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo
dc.description.affiliationInstituto de Investigação em Imunologia - Instituto Nacional de Ciências e Tecnologia-iii-INCT, São Paulo
dc.description.affiliationDepartamento de Clínica Médica Disciplina de Alergia e Imunologia Clínica Faculdade de Medicina da Universidade de São Paulo, São Paulo
dc.description.affiliationUnespSchool of Medicine Universidade Estadual Paulista
dc.format.extent207-215
dc.identifierhttp://dx.doi.org/10.1016/j.ijid.2023.01.042
dc.identifier.citationInternational Journal of Infectious Diseases, v. 129, p. 207-215.
dc.identifier.doi10.1016/j.ijid.2023.01.042
dc.identifier.issn1878-3511
dc.identifier.issn1201-9712
dc.identifier.scopus2-s2.0-85149205945
dc.identifier.urihttp://hdl.handle.net/11449/249043
dc.language.isoeng
dc.relation.ispartofInternational Journal of Infectious Diseases
dc.sourceScopus
dc.subjectCOVID-19
dc.subjectSARS-CoV-2
dc.subjectTurner syndrome
dc.subjectX-chromosome
dc.titleImmunological evaluation of young unvaccinated patients with Turner syndrome after COVID-19en
dc.typeArtigo
unesp.author.orcid0000-0002-8895-652X[1]
unesp.author.orcid0000-0002-0868-0210 0000-0002-0868-0210[7]
unesp.author.orcid0000-0003-0285-4432 0000-0003-0285-4432[8]
unesp.author.orcid0000-0003-0864-2414 0000-0003-0864-2414[9]
unesp.author.orcid0000-0001-5271-4011 0000-0001-5271-4011 0000-0001-5271-4011[12]
unesp.author.orcid0000-0002-3699-3345 0000-0002-3699-3345[13]

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Artigos - Dermatologia e Radioterapia - FMB
Artigos - Microbiologia e Imunologia - IBB