Exposure time and ventricular remodeling induced by tobacco smoke exposure in rats

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dc.contributor.authorCastardeli, Edson [UNESP]
dc.contributor.authorDuarte, Daniella R. [UNESP]
dc.contributor.authorMinicucci, Marcos F. [UNESP]
dc.contributor.authorAzevedo, Paula S. [UNESP]
dc.contributor.authorMatsubara, Beatriz B. [UNESP]
dc.contributor.authorMatsubara, Luiz S. [UNESP]
dc.contributor.authorCampana, Álvaro O. [UNESP]
dc.contributor.authorPaiva, Sergio A. R. [UNESP]
dc.contributor.authorZornoff, Leonardo A. M. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-04-28T20:39:01Z
dc.date.available2022-04-28T20:39:01Z
dc.date.issued2008-03-01
dc.description.abstractBackground: We investigated the effects of length of exposure to tobacco smoke on the cardiac remodeling process induced by exposure to cigarette smoke in rats. Material/Methods: Rats were separated into 4 groups: nonsmoking (NS)2 (n=25; control animals not exposed to tobacco smoke for 2 months), smoking (S)2 (n=22; rats exposed to smoke from 40 cigarettes/d for 2 months), NS6 (n=18; control animals not exposed to tobacco smoke for 6 months), and S6 (n=25; rats exposed to smoke from 40 cigarettes/d for 6 months). All animals underwent echocardiographic, isolated heart, and morphometric studies. Data were analyzed with a 2-way analysis of variance. Results: No interaction among the variables was found; this suggests that length of exposure to tobacco smoke did not influence the effects of exposure to smoke. Values for left ventricular diastolic diameter/body weight and left atrium/body weight were higher (p=0.023 and p=0.001, respectively) in smoking (S2 and S6) than in nonsmoking animals (NS2 and NS6). Left ventricular mass index was higher (p=0.048) in smoking than in nonsmoking animals. In the isovolumetrically beating ventricle, peak systolic pressure was higher (p=0.034) in smoking than in nonsmoking animals. Significantly higher values were found for left ventricular weight (p=0.017) and right ventricular weight (p=0.001) adjusted for body weight in smoking as opposed to nonsmoking animals. Systolic pressure was higher (p=0.001) in smoking (128±14 mm Hg) than in nonsmoking animals (112±11 mm Hg). Conclusions: Length of exposure to cigarette smoke did not influence cardiac remodeling caused by exposure to smoke in rats. © Med Sci Monit, 2008.en
dc.description.affiliationInternal Medicine Department Botucatu Medical School UNESP - São Paulo State University, Botucatu
dc.description.affiliationDepartamento de Clínica Médica Faculdade de Medicina de Botucatu, Rubião Júnior s/n, Botucatu, SP, CEP: 18618-000
dc.description.affiliationUnespInternal Medicine Department Botucatu Medical School UNESP - São Paulo State University, Botucatu
dc.description.affiliationUnespDepartamento de Clínica Médica Faculdade de Medicina de Botucatu, Rubião Júnior s/n, Botucatu, SP, CEP: 18618-000
dc.identifier.citationMedical Science Monitor, v. 14, n. 3, 2008.
dc.identifier.issn1234-1010
dc.identifier.issn1643-3750
dc.identifier.scopus2-s2.0-41449118682
dc.identifier.urihttp://hdl.handle.net/11449/225091
dc.language.isoeng
dc.relation.ispartofMedical Science Monitor
dc.sourceScopus
dc.subjectFibrosis
dc.subjectVentricular dilatation
dc.subjectVentricular function
dc.titleExposure time and ventricular remodeling induced by tobacco smoke exposure in ratsen
dc.typeArtigo

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