Bisphenol-A promotes antiproliferative effects during neonatal prostate development in male and female gerbils

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dc.contributor.authorLima, Rodrigo Fernandes de
dc.contributor.authorRodriguez, Daniel Andrés Osório
dc.contributor.authorCampos, Mônica Souza [UNESP]
dc.contributor.authorBiancardi, Manoel Francisco
dc.contributor.authorSantos, Iana Figueiredo Ferreira Roriz dos
dc.contributor.authorOliveira, Wendyson Duarte de
dc.contributor.authorCavasin, Gláucia Maria
dc.contributor.authorMarques, Mara Rubia
dc.contributor.authorTaboga, Sebastião Roberto [UNESP]
dc.contributor.authorAlcantara dos Santos, Fernanda Cristina
dc.contributor.institutionUniversidade Federal de Goiás (UFG)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-12-07T15:40:05Z
dc.date.available2015-12-07T15:40:05Z
dc.date.issued2015-10-31
dc.description.abstractThe aim of this study was to evaluate the development of male and female neonatal gerbil prostate under normal conditions and exposed to bisphenol-A (BPA). Normal postnatal development of the female gerbil prostate occurs earlier than and is morphologically distinct from that occurring in males. In BPA-exposed PND8 gerbils, we have not observed evidence of alterations in the ductal branching in either gender. However, the exposure to BPA alters the immunolabeling pattern of AR, ERα, and PCNA. In males, the exposure to high dosages of BPA resulted in a decrease in the proliferative status of the developing ventral prostate. In females, both high and low dosages were sufficient to decrease the proliferation of paraurethral buds in the branching process by more than 50%. Therefore, the obtained data indicate that BPA promotes antiproliferative effects during the neonatal development of the gerbil prostate, with more sensitivity to this endocrine disruptor in females.en
dc.description.affiliationDepartment of Histology, Embryology and Cell Biology, Federal University of Goiás, Samambaia II, Goiânia, Goiás 74001970, Brazil
dc.description.affiliationSão Paulo State University - UNESP, Department of Biology, Laboratory of Microscopy and Microanalysis, Rua Cristóvão Colombo, 2265, São José do Rio Preto, São Paulo, 15054000, Brazil
dc.description.affiliationDepartment of Histology, Embryology and Cell Biology, Federal University of Goiás, Samambaia II, Goiânia, Goiás 74001970, Brazil
dc.description.affiliationUnespSão Paulo State University - UNESP, Department of Biology, Laboratory of Microscopy and Microanalysis, Rua Cristóvão Colombo, 2265, São José do Rio Preto, São Paulo, 15054000, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnol[ogico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de Goiás (FAPEG)
dc.format.extent238–245
dc.identifierhttp://dx.doi.org/10.1016/j.reprotox.2015.10.016
dc.identifier.citationReproductive Toxicology (elmsford, N.y.), v. 58, p. 238–245, 2015.
dc.identifier.doi10.1016/j.reprotox.2015.10.016
dc.identifier.issn1873-1708
dc.identifier.orcid0000-0002-0970-4288
dc.identifier.pubmed26529182
dc.identifier.urihttp://hdl.handle.net/11449/131676
dc.language.isoeng
dc.publisherElsevier B. V.
dc.relation.ispartofReproductive Toxicology (elmsford, N.y.)
dc.rights.accessRightsAcesso restrito
dc.sourcePubMed
dc.subjectAr antagonistsen
dc.subjectEndocrine-disrupting chemicalsen
dc.subjectGerbilen
dc.subjectProstatic morphogenesisen
dc.titleBisphenol-A promotes antiproliferative effects during neonatal prostate development in male and female gerbilsen
dc.typeArtigo
dcterms.rightsHolderElsevier B. V.
unesp.author.orcid0000-0002-0970-4288[9]

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