Quantity of IL-2, IL-4, IL-10, INF-γ, TNF-α and KC-Like cytokines in serum of Bitches with pyometra in different stages of oestrous cycle and Pregnancy

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dc.contributor.authorMaciel, G. S.
dc.contributor.authorUscategui, R. R.
dc.contributor.authorde Almeida, V. T.
dc.contributor.authorOliveira, M. E.F.
dc.contributor.authorFeliciano, M. A.R.
dc.contributor.authorVicente, W. R.R.
dc.date.accessioned2022-04-29T08:44:50Z
dc.date.available2022-04-29T08:44:50Z
dc.date.issued2014-01-01
dc.description.abstractThe occurrence of the pyometra is most common in the first half of the dioestrus when there is decreased cellular immunity associated with increased serum concentration of progesterone in females. The aim of this study was to determine the immunological profile of bitches with pyometra, studying serum levels of IL-2, IL-4, IL-10, IFN-γ, KC-like and TNF-α and comparing them with those of healthy bitches in anoestrus, dioestrus and pregnant. Forty females were divided into four experimental groups: group 1 (G1): with pyometra (n = 10); group 2 (G2): bitches in the second week of gestation (n = 10); group 3 (G3): in anoestrus (n = 10); and group 4 (G4): in dioestrus (n = 10). The serum levels for IL-2, KC-like, INF-γ and TNF-α were similar for all experimental groups. The values obtained for IL-10 were found increased (p < 0.001) in animals in dioestrus and pyometra compared with females in anoestrus and pregnant, and the levels of IL-4 observed were significantly greater (p < 0.001) in bitches with pyometra when compared with others. The cytokine profile in animals with pyometra is similar to bitches in dioestrus for IL-10 and had increase in IL-4 for bitches with pyometra, which represents an anti-inflammatory these cases. This suggests the presence of an immunosuppressive state in both cases, which may explain the propensity of bitches in dioestrus to be affected by pyometra and the severity of the disease on these animals. © 2014 Blackwell Verlag GmbH.en
dc.description.affiliationDepartment of Animal Reproduction, College of Agricultural and Veterinary Sciences - Sao aulo State University, Jaboticabal
dc.format.extent701-704
dc.identifierhttp://dx.doi.org/10.1111/rda.12360
dc.identifier.citationReproduction in Domestic Animals, v. 49, n. 4, p. 701-704, 2014.
dc.identifier.doi10.1111/rda.12360
dc.identifier.issn1439-0531
dc.identifier.issn0936-6768
dc.identifier.scopus2-s2.0-84904046529
dc.identifier.urihttp://hdl.handle.net/11449/231335
dc.language.isoeng
dc.relation.ispartofReproduction in Domestic Animals
dc.sourceScopus
dc.titleQuantity of IL-2, IL-4, IL-10, INF-γ, TNF-α and KC-Like cytokines in serum of Bitches with pyometra in different stages of oestrous cycle and Pregnancyen
dc.typeArtigo
unesp.departmentMedicina Veterinária Preventiva e Reprodução Animal - FCAVpt

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Jaboticabal - FCAV - Faculdade de Ciências Agrárias e Veterinárias