Biocompatibility and biomineralization ability of Bio-C Pulpecto. A histological and immunohistochemical study

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dc.contributor.authorCosme-Silva, Leopoldo [UNESP]
dc.contributor.authorBenetti, Francine [UNESP]
dc.contributor.authorDal Fabbro, Renan [UNESP]
dc.contributor.authorGomes Filho, João Eduardo [UNESP]
dc.contributor.authorSakai, Vivien T.
dc.contributor.authorCintra, Luciano T. A. [UNESP]
dc.contributor.authorAlvarez, Nathalia
dc.contributor.authorErvolino, Edilson [UNESP]
dc.contributor.authorViola, Naiana V.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionFederal University of Alfenas (UNIFAL-MG)
dc.date.accessioned2019-10-06T16:16:13Z
dc.date.available2019-10-06T16:16:13Z
dc.date.issued2019-05-01
dc.description.abstractAim: To evaluate the inflammatory response, biomineralization and production of osteocalcin (OCN), osteopontin (OPN), and bone sialoprotein (BSP) of a new root filling material for primary teeth (Bio-C Pulpecto) compared to MTA. Design: Polyethylene tubes containing Bio-C Pulpecto, MTA, and empty tubes were implanted into the dorsal connective tissue. After 7, 15, 30, 60, and 90 days, the tubes with surrounding tissue were removed and histologically processed to be analysed using haematoxylin and eosin, von Kossa staining, or no staining for observation under polarized light and immunohistochemistry for the detection of OCN, OPN, and BSP. The Kruskal-Wallis test was used followed by Dunn's test. The significance level was set at 5%. Results: The inflammatory response observed with MTA and Bio-C Pulpecto was more exacerbated until the 15th day and decreased from 30 days on. No significant difference was found between control, MTA, and Bio-C Pulpecto (P > 0.05). Bio-C Pulpecto and MTA showed positivity for von Kossa and birefringent to polarized light. The immunolabelling for OCN, OPN, and BSP was more intense for MTA and Bio-C Pulpecto on days 60 and 90 (P > 0.05). Conclusion: Bio-C Pulpecto was biocompatible, induced biomineralization and was immunopositive for osteogenic markers such as OCN, OPN, and BSP, similarly to MTA.en
dc.description.affiliationDepartment of Restorative Dentistry Araçatuba Dental School Endodontics UNESP-Univ Estadual Paulista
dc.description.affiliationDepartment of Clinics and Surgery School of Dentistry Federal University of Alfenas (UNIFAL-MG)
dc.description.affiliationDepartment of Basic Science School of Dentistry São Paulo State University (UNESP)
dc.description.affiliationUnespDepartment of Restorative Dentistry Araçatuba Dental School Endodontics UNESP-Univ Estadual Paulista
dc.description.affiliationUnespDepartment of Basic Science School of Dentistry São Paulo State University (UNESP)
dc.format.extent352-360
dc.identifierhttp://dx.doi.org/10.1111/ipd.12464
dc.identifier.citationInternational Journal of Paediatric Dentistry, v. 29, n. 3, p. 352-360, 2019.
dc.identifier.doi10.1111/ipd.12464
dc.identifier.issn1365-263X
dc.identifier.issn0960-7439
dc.identifier.lattes4408095517346846
dc.identifier.orcid0000-0003-4859-0583
dc.identifier.scopus2-s2.0-85060955171
dc.identifier.urihttp://hdl.handle.net/11449/188693
dc.language.isoeng
dc.relation.ispartofInternational Journal of Paediatric Dentistry
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectbioactivity
dc.subjectbiomineralization
dc.subjectpulpectomy
dc.subjecttooth primary
dc.titleBiocompatibility and biomineralization ability of Bio-C Pulpecto. A histological and immunohistochemical studyen
dc.typeArtigo
unesp.author.lattes4408095517346846[8]
unesp.author.orcid0000-0002-5755-1933[1]
unesp.author.orcid0000-0002-5459-353X[2]
unesp.author.orcid0000-0002-4125-8441[3]
unesp.author.orcid0000-0001-5994-2287[4]
unesp.author.orcid0000-0002-5574-4539[5]
unesp.author.orcid0000-0003-4859-0583[8]
unesp.author.orcid0000-0001-8097-892X[9]

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Artigos - Odontologia Restauradora - FOA