Biodiversidade: fonte potencial para a descoberta de fármacos

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dc.contributor.authorBarreiro, Eliezer J.
dc.contributor.authorBolzani, Vanderlan da Silva [UNESP]
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T14:20:00Z
dc.date.available2014-05-20T14:20:00Z
dc.date.issued2009-01-01
dc.description.abstractIn economic terms, biodiversity transcends the boundaries usually given to conventional industries because it is a valuable source of biological and chemical data of great use to drug discovery. Certainly, the use of natural products has been the single most successful strategy in the discovery of novel medicines, and most of the medical breakthroughs are based on natural products. Half of the top 20 best-selling drugs are natural products, and their total sales amounted to US$ 16 billions shows the importance of natural products, which is evidenced by the new chemical entities (NCE) approved by regulatory authorities around the world in the past decade. Recently, the approval of the alkaloid galanthamine as a medicine to treat Alzheimer's disease shows that natural compounds from plants will continue to reach the market. The huge biological diversity of the Brazilian biomes, by its ability to generate new knowledge and technological innovation can be a fantastic alternative as raw material for drug discovery.en
dc.description.affiliationUniv Fed Rio de Janeiro, Dept Farmacos, Fac Farm, Ctr Ciencias Saude, BR-21944910 Rio de Janeiro, Brazil
dc.description.affiliationUniversidade Estadual Paulista Instituto de Química, BR-14800900 Araraquara, SP, Brazil
dc.description.affiliationUnespUniversidade Estadual Paulista Instituto de Química, BR-14800900 Araraquara, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent679-688
dc.identifierhttp://dx.doi.org/10.1590/S0100-40422009000300012
dc.identifier.citationQuímica Nova. Sociedade Brasileira de Química, v. 32, n. 3, p. 679-688, 2009.
dc.identifier.doi10.1590/S0100-40422009000300012
dc.identifier.fileS0100-40422009000300012.pdf
dc.identifier.issn0100-4042
dc.identifier.lattes4484083685251673
dc.identifier.scieloS0100-40422009000300012
dc.identifier.urihttp://hdl.handle.net/11449/26002
dc.identifier.wosWOS:000266551600012
dc.language.isopor
dc.publisherSociedade Brasileira de Química
dc.relation.ispartofQuímica Nova
dc.relation.ispartofjcr0.646
dc.relation.ispartofsjr0,255
dc.rights.accessRightsAcesso aberto
dc.sourceSciELO
dc.subjectbiodiversityen
dc.subjectnatural productsen
dc.subjectdrugsen
dc.subjectmedicinal chemistryen
dc.titleBiodiversidade: fonte potencial para a descoberta de fármacospt
dc.title.alternativeBiodiversity: potential source for drug discoveryen
dc.typeArtigo
unesp.author.lattes4484083685251673
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt

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Artigos - Química Orgânica - IQ