Identification of Novel Genes Associated with Fish Skeletal Muscle Adaptation during Fasting and Refeeding Based on a Meta-Analysis

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dc.contributor.authorPerez, Érika Stefani [UNESP]
dc.contributor.authorCury, Sarah Santiloni [UNESP]
dc.contributor.authorZanella, Bruna Tereza Thomazini [UNESP]
dc.contributor.authorCarvalho, Robson Francisco [UNESP]
dc.contributor.authorDuran, Bruno Oliveira Silva
dc.contributor.authorDal-Pai-Silva, Maeli [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionFederal University of Goias (UFG)
dc.date.accessioned2023-07-29T16:01:23Z
dc.date.available2023-07-29T16:01:23Z
dc.date.issued2022-12-01
dc.description.abstractThe regulation of the fish phenotype and muscle growth is influenced by fasting and refeeding periods, which occur in nature and are commonly applied in fish farming. However, the regulators associated with the muscle responses to these manipulations of food availability have not been fully characterized. We aimed to identify novel genes associated with fish skeletal muscle adaptation during fasting and refeeding based on a meta-analysis. Genes related to translational and proliferative machinery were investigated in pacus (Piaractus mesopotamicus) subjected to fasting (four and fifteen days) and refeeding (six hours, three and fifteen days). Our results showed that different fasting and refeeding periods modulate the expression of the genes mtor, rps27a, eef1a2, and cdkn1a. These alterations can indicate the possible protection of the muscle phenotype, in addition to adaptive responses that prioritize energy and substrate savings over cell division, a process regulated by ccnd1. Our study reveals the potential of meta-analysis for the identification of muscle growth regulators and provides new information on muscle responses to fasting and refeeding in fish that are of economic importance to aquaculture.en
dc.description.affiliationDepartment of Structural and Functional Biology São Paulo State University (UNESP)
dc.description.affiliationDepartment of Histology Embryology and Cell Biology Federal University of Goias (UFG)
dc.description.affiliationUnespDepartment of Structural and Functional Biology São Paulo State University (UNESP)
dc.identifierhttp://dx.doi.org/10.3390/genes13122378
dc.identifier.citationGenes, v. 13, n. 12, 2022.
dc.identifier.doi10.3390/genes13122378
dc.identifier.issn2073-4425
dc.identifier.scopus2-s2.0-85144697918
dc.identifier.urihttp://hdl.handle.net/11449/249502
dc.language.isoeng
dc.relation.ispartofGenes
dc.sourceScopus
dc.subjectfasting
dc.subjectfish
dc.subjectmeta-analysis
dc.subjectpacu
dc.subjectPiaractus mesopotamicus
dc.subjectrefeeding
dc.subjectskeletal muscle growth
dc.titleIdentification of Novel Genes Associated with Fish Skeletal Muscle Adaptation during Fasting and Refeeding Based on a Meta-Analysisen
dc.typeArtigo
unesp.author.orcid0000-0002-7435-0201[1]
unesp.author.orcid0000-0002-4803-0933[2]
unesp.author.orcid0000-0002-5964-4148[3]
unesp.author.orcid0000-0002-4901-7714[4]
unesp.author.orcid0000-0002-7920-8175[5]
unesp.author.orcid0000-0001-7269-9197[6]

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