Susceptibility of strict and facultative anaerobes isolated from endodontic infections to metronidazole and β-lactams

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dc.contributor.authorGaetti-Jardim Jr., Elerson [UNESP]
dc.contributor.authorLanducci, Luís Fernando
dc.contributor.authorLins, Samira Âmbar
dc.contributor.authorVieira, Evanice Menezes Marçal
dc.contributor.authorDe Oliveira, Sérgio Ricardo [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUNIRP
dc.contributor.institutionSchool of Dentistry of Santa Fé do Sul
dc.contributor.institutionUNIC
dc.date.accessioned2014-05-27T11:22:38Z
dc.date.available2014-05-27T11:22:38Z
dc.date.issued2007-11-01
dc.description.abstractEndodontic infections are mixed aerobic-anaerobic infections and several microbial groups associated to these pathologies are also involved in orofacial infections. The goal of this study was to evaluate the susceptibility of microorganisms isolated from endodontic infections to β-lactams and metronidazole and verify the production of β-lactamases. Clinical specimens were collected from 58 endodontic infections of 52 patients. The microorganisms were isolated in selective and non-selective culture media, under anaerobiosis and aerobiosis, and identified using biochemical methods. In the susceptibility tests, it was used an agar dilution method, and Wilkins-Chalgren agar enriched with blood, hemin and menadione for the anaerobes, while Mueller-Hinton agar was employed for the facultative anaerobes. The production of β-lactamases was evaluated through the biological and chromogenic cephalosporin methods. All tested isolates were sensitive to imipenem and 99.3% to amoxicillin/clavulanate association, while 16.1% showed resistance to amoxicillin and penicillin G, and 4.89% to cefoxitin. Resistance to metronidazole was just found in facultative anaerobes. Production of β-lactamases was detected in 18.2% of the isolates and presented a correlation with resistance to β-lactams.en
dc.description.affiliationDepartment of Pathology and Propedeutics Clinic Dental School of Araçatuba São Paulo State University, Araçatuba, SP
dc.description.affiliationDepartment of Microbiology and Immunology UNIRP
dc.description.affiliationSchool of Dentistry of Santa Fé do Sul
dc.description.affiliationDepartment of Pathology UNIC
dc.description.affiliationDental School of Araçatuba São Paulo State University, Araçatuba, SP
dc.description.affiliationFaculdade de Odontologia de Araçatuba UNESP, Rua Jose Bonifácio, 1193, 16015-500 Araçatuba, SP
dc.description.affiliationUnespDepartment of Pathology and Propedeutics Clinic Dental School of Araçatuba São Paulo State University, Araçatuba, SP
dc.description.affiliationUnespDental School of Araçatuba São Paulo State University, Araçatuba, SP
dc.description.affiliationUnespFaculdade de Odontologia de Araçatuba UNESP, Rua Jose Bonifácio, 1193, 16015-500 Araçatuba, SP
dc.format.extent539-545
dc.identifierhttp://dx.doi.org/10.1590/S1678-77572007000600016
dc.identifier.citationJournal of Applied Oral Science, v. 15, n. 6, p. 539-545, 2007.
dc.identifier.doi10.1590/S1678-77572007000600016
dc.identifier.file2-s2.0-38049185398.pdf
dc.identifier.issn1678-7757
dc.identifier.issn1678-7765
dc.identifier.scieloS1678-77572007000600016
dc.identifier.scopus2-s2.0-38049185398
dc.identifier.urihttp://hdl.handle.net/11449/69960
dc.identifier.wosWOS:000256795100015
dc.language.isoeng
dc.relation.ispartofJournal of Applied Oral Science
dc.relation.ispartofjcr1.709
dc.relation.ispartofsjr0,645
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectβ-lactams
dc.subjectAntibacterial agents
dc.subjectInfection
dc.titleSusceptibility of strict and facultative anaerobes isolated from endodontic infections to metronidazole and β-lactamsen
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/jaos/iaboutj.htm
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araçatubapt

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Artigos - Patologia e Propedêutica Clínica - FOA