Host organism defense by a peptide-polysaccharide extracted from the fungus Sporothrix schenckii

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dc.contributor.authorCarlos, Iracilda Zeppone [UNESP]
dc.contributor.authorSgarbi, DBD
dc.contributor.authorPlaceres, MCP
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal Fluminense (UFF)
dc.date.accessioned2014-05-20T15:25:20Z
dc.date.available2014-05-20T15:25:20Z
dc.date.issued1998-01-01
dc.description.abstractA peptide-polysaccharide, a peptide-rhamnomannan, was isolated from the pathogenic yeast form of the fungus Sporothrix schenckii. This substance, which may play a role in fungal virulence, was tested in an animal model of systemic disease, and depression of the immune response was observed in the animals between the 4th and 6th week of infection. Concomitantly, this compound showed mitogenic activity when challenged with normal lymphocytes and was also found to be involved in the inflammatory response. These results provide further information for the understanding of fungal implantation in tissues and of the pathogenicity of this systemic mycosis.en
dc.description.affiliationUniv Paulista Julio Mesquita Filho, Fac Ciências Farmaceut Araraquara, Dept Anal Clin, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUniv Fed Fluminense, Inst Biomed, Dept Microbiol & Parasitol, Niteroi, RJ, Brazil
dc.description.affiliationUnespUniv Paulista Julio Mesquita Filho, Fac Ciências Farmaceut Araraquara, Dept Anal Clin, BR-14801902 Araraquara, SP, Brazil
dc.format.extent9-14
dc.identifierhttp://dx.doi.org/10.1023/A:1006964516334
dc.identifier.citationMycopathologia. Dordrecht: Kluwer Academic Publ, v. 144, n. 1, p. 9-14, 1998.
dc.identifier.doi10.1023/A:1006964516334
dc.identifier.issn0301-486X
dc.identifier.lattes1730146818754269
dc.identifier.urihttp://hdl.handle.net/11449/35774
dc.identifier.wosWOS:000080783600002
dc.language.isoeng
dc.publisherKluwer Academic Publ
dc.relation.ispartofMycopathologia
dc.relation.ispartofjcr1.476
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectimmune and inflammatory responsespt
dc.subjectmitogenic activity peptide-polysaccharidept
dc.subjectSporothrix schenckiipt
dc.titleHost organism defense by a peptide-polysaccharide extracted from the fungus Sporothrix schenckiien
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights
dcterms.rightsHolderKluwer Academic Publ
unesp.author.lattes1730146818754269
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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Artigos - Análises Clínicas - FCFAR