The carotid body: A novel key player in neuroimmune interactions

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dc.contributor.authorKatayama, Pedro L. [UNESP]
dc.contributor.authorLeirão, Isabela P. [UNESP]
dc.contributor.authorKanashiro, Alexandre
dc.contributor.authorMenani, José V. [UNESP]
dc.contributor.authorZoccal, Daniel B. [UNESP]
dc.contributor.authorColombari, Débora S. A. [UNESP]
dc.contributor.authorColombari, Eduardo [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2023-07-29T13:59:40Z
dc.date.available2023-07-29T13:59:40Z
dc.date.issued2022-10-24
dc.description.abstractThe idea that the nervous system communicates with the immune system to regulate physiological and pathological processes is not new. However, there is still much to learn about how these interactions occur under different conditions. The carotid body (CB) is a sensory organ located in the neck, classically known as the primary sensor of the oxygen (O2) levels in the organism of mammals. When the partial pressure of O2 in the arterial blood falls, the CB alerts the brain which coordinates cardiorespiratory responses to ensure adequate O2 supply to all tissues and organs in the body. A growing body of evidence, however, has demonstrated that the CB is much more than an O2 sensor. Actually, the CB is a multimodal sensor with the extraordinary ability to detect a wide diversity of circulating molecules in the arterial blood, including inflammatory mediators. In this review, we introduce the literature supporting the role of the CB as a critical component of neuroimmune interactions. Based on ours and other studies, we propose a novel neuroimmune pathway in which the CB acts as a sensor of circulating inflammatory mediators and, in conditions of systemic inflammation, recruits a sympathetic-mediated counteracting mechanism that appears to be a protective response.en
dc.description.affiliationDepartment of Physiology and Pathology School of Dentistry São Paulo State University, São Paulo
dc.description.affiliationDepartment of Neurosciences and Behavior Ribeirão Preto Medical School University of São Paulo
dc.description.affiliationUnespDepartment of Physiology and Pathology School of Dentistry São Paulo State University, São Paulo
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: #2015/23467-7
dc.description.sponsorshipIdFAPESP: #2019/11196-0
dc.description.sponsorshipIdFAPESP: #2019/24154-3
dc.identifierhttp://dx.doi.org/10.3389/fimmu.2022.1033774
dc.identifier.citationFrontiers in Immunology, v. 13.
dc.identifier.doi10.3389/fimmu.2022.1033774
dc.identifier.issn1664-3224
dc.identifier.scopus2-s2.0-85141704164
dc.identifier.urihttp://hdl.handle.net/11449/249000
dc.language.isoeng
dc.relation.ispartofFrontiers in Immunology
dc.sourceScopus
dc.subjectCarotid body
dc.subjectinflammation
dc.subjectneuroimmune interactions
dc.subjectneuroimmunomodulation
dc.subjectsympathetic nervous system
dc.titleThe carotid body: A novel key player in neuroimmune interactionsen
dc.typeResenha

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Artigos - Neurologia, Psicologia e Psiquiatria - FMB