Obesity and Hyperlipidemia Modulate Alveolar Bone Loss in Wistar Rats

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dc.contributor.authorCavagni, Juliano
dc.contributor.authorMacedo, Isabel Cristina de
dc.contributor.authorGaio, Eduardo Jose
dc.contributor.authorSouza, Andressa
dc.contributor.authorMolon, Rafael Scaf de [UNESP]
dc.contributor.authorCirelli, Joni Augusto [UNESP]
dc.contributor.authorHoefel, Ana Lucia
dc.contributor.authorKucharski, Luiz Carlos
dc.contributor.authorSilva Torres, Iraci Lucena da
dc.contributor.authorRoesing, Cassiano Kuchenbecker
dc.contributor.institutionUniv Fed Rio Grande do Sul
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-11-26T16:19:25Z
dc.date.available2018-11-26T16:19:25Z
dc.date.issued2016-02-02
dc.description.abstractBackground: A positive association between obesity-associated metabolic disorders (e.g., hyperlipidemia and diabetes) and periodontitis has been demonstrated in the literature. This study evaluates the role of cafeteria diet-induced obesity/hyperlipidemia (CAF) on alveolar bone loss (ABL) in rats. Methods: Sixty male Wistar rats were randomly divided in four groups: control, periodontitis (PERIO), obesity/hyperlipidemia (CAF), and obesity/hyperlipidemia plus periodontitis (CAF+PERIO). Groups CAF and CAF+PERIO were exposed to a high-fat, hypercaloric diet. At week 12, periodontal disease was induced in groups PERIO and CAF+PERIO by ligatures in the upper second molar. The contralateral tooth was considered the intragroup control. Body weight and Lee index were evaluated weekly during the experiment. Serum glucose and cholesterol/triglycerides in the liver were evaluated, and percentage of ABL was measured by microcomputed tomography. Serum tumor necrosis factor (TNF)-alpha and interleukin (IL)-1 beta were evaluated by enzyme-linked immunosorbent assay at week 17. Results: Body weight, Lee index, and cholesterol/triglycerides in the liver increased in groups exposed to the cafeteria diet. Groups PERIO and CAF+PERIO exhibited a significantly higher ABL compared to control and CAF groups. The presence of obesity and hyperlipidemia significantly increased ABL in the CAF+PERIO group compared to the PERIO group (53.60 +/- 3.44 versus 42.78 +/- 7.27, respectively) in the sides with ligature. Groups exposed to CAF exhibited higher ABL in the sides without ligature. No differences were observed among groups for IL-1 beta and TNF-alpha. Conclusion: Obesity and hyperlipidemia modulate the host response to challenges in the periodontium, increasing the expression of periodontal breakdown.en
dc.description.affiliationUniv Fed Rio Grande do Sul, Dept Periodontol, BR-90046900 Porto Alegre, RS, Brazil
dc.description.affiliationUniv Fed Rio Grande do Sul, Inst Basic Hlth Sci, Dept Pharmacol, BR-90046900 Porto Alegre, RS, Brazil
dc.description.affiliationSao Paulo State Univ, Dept Diag & Surg, Araraquara, Brazil
dc.description.affiliationUniv Fed Rio Grande do Sul, Basic Hlth Sci Inst, Dept Physiol, Lab Metab & Comparat Endocrinol, BR-90046900 Porto Alegre, RS, Brazil
dc.description.affiliationUnespSao Paulo State Univ, Dept Diag & Surg, Araraquara, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIncentive Fund for Research and Events of the Hospital de Clinicas de Porto Alegre, Brazil (FIPE)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdCAPES: PROCAD NF
dc.description.sponsorshipIdIncentive Fund for Research and Events of the Hospital de Clinicas de Porto Alegre, Brazil (FIPE): 110051
dc.format.extentE9-E17
dc.identifierhttp://dx.doi.org/10.1902/jop.2015.150330
dc.identifier.citationJournal Of Periodontology. Chicago: Amer Acad Periodontology, v. 87, n. 2, p. E9-E17, 2016.
dc.identifier.doi10.1902/jop.2015.150330
dc.identifier.issn0022-3492
dc.identifier.urihttp://hdl.handle.net/11449/161171
dc.identifier.wosWOS:000369132500001
dc.language.isoeng
dc.publisherAmer Acad Periodontology
dc.relation.ispartofJournal Of Periodontology
dc.relation.ispartofsjr1,408
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectDiet
dc.subjecthyperlipidemias
dc.subjectmicrocomputed tomography
dc.subjectobesity
dc.subjectperiodontal diseases
dc.subjectrats
dc.titleObesity and Hyperlipidemia Modulate Alveolar Bone Loss in Wistar Ratsen
dc.typeArtigo
dcterms.rightsHolderAmer Acad Periodontology
unesp.author.orcid0000-0002-6608-4695[4]
unesp.author.orcid0000-0003-1110-6233[5]

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