Apoptosis in tongue squamous cell carcinoma and its correlation with clinically occult cervical metastasis

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dc.contributor.authorMolina, Fernando D. [UNESP]
dc.contributor.authorBertollo, Eny M. G. [UNESP]
dc.contributor.authorAssis, Claudiane M. [UNESP]
dc.contributor.authorFalleiros, Luis R. [UNESP]
dc.contributor.authorCampos, Silvana G. P. [UNESP]
dc.contributor.authorManiglia, Jose V. [UNESP]
dc.contributor.authorTaboga, Sebastiao R. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T14:01:01Z
dc.date.available2014-05-20T14:01:01Z
dc.date.issued2008-10-01
dc.description.abstractSquamous cell carcinoma of the tongue is one of the most common head and neck cancer. Treatment in the early stages is still controversial. This study aims to correlate the apoptosis rate of primary tongue cancer with cervical node metastasis, found in the histopathological studies of specimens obtained from neck dissections or during clinical follow-up. Twenty patients, 65% males, mean age 64.5 years, without clinical evidence of cervical metastasis was included. Eighty-five percent were smokers and 40% were alcohol abusers. Mann-Whitney test was used for statistical analysis (p <= 0.05). Five patients with clinically occult cervical metastases had metastasis in the histopathological specimens (25%) occult metastasis. The mean apoptosis rate in patients without cervical metastasis was 9.43%. Twenty-five percent of the patients had occult cervical metastasis. High apoptosis rate in tongue cancer, even in the absence of palpable neck nodes, correlates with the presence of occult metastasis. (C) 2007 Elsevier Ltd. All rights reserved.en
dc.description.affiliationUNESP, São Paulo State Univ, Inst Biosci Human & Exact Sci, Dept Otorinolaryngol, Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationUNESP, São Paulo State Univ, Inst Biosci Human & Exact Sci, Head & Neck Surg Serv, Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationUNESP, São Paulo State Univ, Inst Biosci Human & Exact Sci, Dept Morphol Sao Jose Rio Preto Med Sch,FAMERP, Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationUNESP, São Paulo State Univ, Inst Biosci Human & Exact Sci, Dept Biol, Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationUnespUNESP, São Paulo State Univ, Inst Biosci Human & Exact Sci, Dept Otorinolaryngol, Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationUnespUNESP, São Paulo State Univ, Inst Biosci Human & Exact Sci, Head & Neck Surg Serv, Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationUnespUNESP, São Paulo State Univ, Inst Biosci Human & Exact Sci, Dept Morphol Sao Jose Rio Preto Med Sch,FAMERP, Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationUnespUNESP, São Paulo State Univ, Inst Biosci Human & Exact Sci, Dept Biol, Sao Jose do Rio Preto, SP, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdCNPq: 301111/05-7
dc.format.extent910-914
dc.identifierhttp://dx.doi.org/10.1016/j.micron.2007.11.006
dc.identifier.citationMicron. Oxford: Pergamon-Elsevier B.V. Ltd, v. 39, n. 7, p. 910-914, 2008.
dc.identifier.doi10.1016/j.micron.2007.11.006
dc.identifier.issn0968-4328
dc.identifier.orcid0000-0002-0970-4288
dc.identifier.urihttp://hdl.handle.net/11449/21561
dc.identifier.wosWOS:000259422800020
dc.language.isoeng
dc.publisherPergamon-Elsevier B.V. Ltd
dc.relation.ispartofMicron
dc.relation.ispartofjcr1.728
dc.relation.ispartofsjr0,624
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectApoptosisen
dc.subjecttongue cancersen
dc.subjectoccult metastasisen
dc.subjectsquamous cell carcinomaen
dc.titleApoptosis in tongue squamous cell carcinoma and its correlation with clinically occult cervical metastasisen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderPergamon-Elsevier B.V. Ltd
unesp.author.orcid0000-0002-0970-4288[7]
unesp.author.orcid0000-0002-9765-2659[6]
unesp.author.orcid0000-0002-2622-4673[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Pretopt

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Artigos - Biologia - IBILCE