A randomized clinical trial of oral steroids for ulnar neuropathy in type 1 and type 2 leprosy reactions

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dc.contributor.authorGarbino, José Antonio
dc.contributor.authorVirmond, Marcos Da Cunha Lopes
dc.contributor.authorUra, Somei
dc.contributor.authorSalgado, Manoel Henrique
dc.contributor.authorNaafs, Bernard
dc.contributor.institutionInstituto Lauro de Souza Lima
dc.contributor.institutionUniversidade do Estado de São Paulo
dc.contributor.institutionUniversidade de Leiden
dc.contributor.institutionInstituto Lauro de Lima
dc.date.accessioned2022-04-29T08:43:57Z
dc.date.available2022-04-29T08:43:57Z
dc.date.issued2008-01-01
dc.description.abstractBackground: Steroids regimens in leprosy neuropathies are still controversial in botth types of reactions. Method: For this trial, 21 patients with ulnar neuropathy were selected from 163 leprosy patients, 12 with type 1 reaction (T1R) and nine with type 2 (T2R). One experimental group started with prednisone 2 mg/kg/day and the control group with 1 mg/kg/day. A clinical score based on tests for spontaneous pain, nerve palpation, sensory and muscle function was used. Neurophysiological evaluation consisted on the motor nerve conduction of the ulnar nerve in three segments. Student t test for statistical analysis was applied on the results: before treatment, first week, first month and sixth month, between each regimen and types of reaction. Conclusion: In both reactions during the first month higher doses of steroids produced better results but, earlier treatment with lower dose was as effective. Short periods of steroid, 1 mg/Kg/day at the beginning and,tapering to 0,5 mg/Kg/day or less in one month turned out to be efficient in T2R.en
dc.description.affiliationInstituto Lauro de Souza Lima, Bauru SP
dc.description.affiliationDepartamento de Produção Faculdade de Engenharia de Bauru Universidade do Estado de São Paulo, Bauru SP
dc.description.affiliationDepartamento de Dermatologia Centro Médico Universidade de Leiden, NLD
dc.description.affiliationInstituto Lauro de Lima, Caixa Postal: 3021, 17034-971 Bauru SP
dc.format.extent861-867
dc.identifierhttp://dx.doi.org/10.1590/S0004-282X2008000600016
dc.identifier.citationArquivos de Neuro-Psiquiatria, v. 66, n. 4, p. 861-867, 2008.
dc.identifier.doi10.1590/S0004-282X2008000600016
dc.identifier.issn1678-4227
dc.identifier.issn0004-282X
dc.identifier.scopus2-s2.0-58149237457
dc.identifier.urihttp://hdl.handle.net/11449/231194
dc.language.isoeng
dc.relation.ispartofArquivos de Neuro-Psiquiatria
dc.sourceScopus
dc.subjectLeprosy
dc.subjectNeurophysiology
dc.subjectSteroids
dc.subjectUlnar neuropathy
dc.titleA randomized clinical trial of oral steroids for ulnar neuropathy in type 1 and type 2 leprosy reactionsen
dc.typeArtigo

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