Antinociceptive and anti-inflammatory properties of aqueous extract obtained from Serjania marginata Casar leaves

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dc.contributor.authorMatos Leitão, Maicon
dc.contributor.authorEuclides Silva-Filho, Saulo
dc.contributor.authorArena, Arielle Cristina [UNESP]
dc.contributor.authorHeredia-Vieira, Silvia Cristina
dc.contributor.authorCardoso, Cláudia Andrea Lima
dc.contributor.authorKassuya, Cândida Aparecida Leite
dc.contributor.institutionFaculty of Health Sciences
dc.contributor.institutionUnigran Capital University Center
dc.contributor.institutionFederal University of Mato Grosso Do Sul
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionAnhanguera-Uniderp University
dc.contributor.institutionState University of Mato Grosso do Sul
dc.date.accessioned2023-07-29T16:01:48Z
dc.date.available2023-07-29T16:01:48Z
dc.date.issued2023-03-25
dc.description.abstractEthnopharmacological relevance: Serjania marginata Casar (Sapindaceae Family) Leaves are popularly used against abdominal pain. Antiulcer properties of S. marginata were scientifically described, however rare studies showed the antinociceptive effects of this plant. Aim of study: In this study, we investigated the antinociceptive and anti-inflammatory effects of aqueous extract obtained from Serjania marginata leaves (AESM) in nociception/inflammation models. Material and methods: AESM was analyzed in FIA-ESI-IT-MS and Mass spectrometer LTQ XL. AESM oral administration (p.o.) (30, 100 and 300 mg/kg), dexamethasone subcutaneous injection (1 mg/kg, s.c.) and morphine (5 mg/kg, s.c.) were tested against the acetic acid-induced nociception, carrageenan-induced acute inflammatory paw edema/hyperalgesia, formalin-induced nociception and carrageenan-induced pleurisy in Swiss mice. Results: Flavonoids rutin was detected in the phytochemical analysis of this extract. Oral treatment of AESM 300 mg/kg significantly reduced the number of acetic acid-induced abdominal writhing. AESM (100 and 300 mg/kg) significantly inhibited formalin-induced nociception, mechanical hyperalgesia and paw edema in carrageenan-model. Furthermore, AESM significantly inhibited leukocyte migration and protein exudation in the carrageenan-induced pleurisy test. Conclusion: This study confirms the antinociceptive, and anti-inflammatory activity of AESM, which may explain, in part, the popular use of this plant as a natural antinociceptive agent. This pharmacological action can be caused by flavonoids such as rutin and other compounds present in AESM.en
dc.description.affiliationFederal University of Grande Dourados Faculty of Health Sciences, Mato Grosso do Sul State
dc.description.affiliationSchool of Health Sciences Unigran Capital University Center, Mato Grosso do Sul State
dc.description.affiliationPharmaceutical Sciences Food and Nutrition College Federal University of Mato Grosso Do Sul, Mato Grosso do Sul State
dc.description.affiliationDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu São Paulo State University, São Paulo State
dc.description.affiliationEnvironment and Regional Development Postgraduate Program Anhanguera-Uniderp University, Mato Grosso do Sul State
dc.description.affiliationCenter of Studies in Natural Resources State University of Mato Grosso do Sul, Mato Grosso do Sul State
dc.description.affiliationUnespDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu São Paulo State University, São Paulo State
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Estado de Mato Grosso do Sul
dc.identifierhttp://dx.doi.org/10.1016/j.jep.2022.116018
dc.identifier.citationJournal of Ethnopharmacology, v. 304.
dc.identifier.doi10.1016/j.jep.2022.116018
dc.identifier.issn1872-7573
dc.identifier.issn0378-8741
dc.identifier.scopus2-s2.0-85144962627
dc.identifier.urihttp://hdl.handle.net/11449/249515
dc.language.isoeng
dc.relation.ispartofJournal of Ethnopharmacology
dc.sourceScopus
dc.subjectcipó-timbó
dc.subjectCipó-uva
dc.subjectInflammation
dc.subjectRutin
dc.subjectStomach pain
dc.titleAntinociceptive and anti-inflammatory properties of aqueous extract obtained from Serjania marginata Casar leavesen
dc.typeArtigo
unesp.author.orcid0000-0003-2699-1511 0000-0003-2699-1511[1]
unesp.author.orcid0000-0002-9676-7622[2]
unesp.author.orcid0000-0002-2373-9399[3]
unesp.author.orcid0000-0002-5506-2677[4]
unesp.author.orcid0000-0002-4907-0056[5]

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