Study of virulence factors in coagulase-negative staphylococci isolated from newborns

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dc.contributor.authorRibeiro de Souza da Cunha, Maria de Lourdes
dc.contributor.authorSuppo de Souza Rugolo, Ligia Maria
dc.contributor.authorMagalhaes Lopes, Carlos Alberto de
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2020-12-10T18:05:48Z
dc.date.available2020-12-10T18:05:48Z
dc.date.issued2006-09-01
dc.description.abstractCoagulase-negative staphylococci (CNS) have been identified as the etiological agent in various infections and are currently the microorganisms most frequently isolated in nosocomial infections. However little is known about the virulence factors produced by CNS that contribute to the pathogenesis of infections caused by these microorganisms. The study of CNS isolated from infectious processes of newborns hospitalized in the Neonatal Unit of the Hospital of the Botucatu Medical School, Unesp, indicated Staphylococcus epidermidis as the most frequently isolated species (77.8%), which was also associated with clinically significant situations. The analysis of virulence factors revealed the production of slime in 20 (17.1%) of all CNS samples isolated and the synthesis of a broad spectrum of enzymes and toxins, including hemolysins (19.6%), lipase (17.1%), lecithinase (3.4%), DNAse (15.4%), thermonuclease (7.7%), and enterotoxin A, B or C (37.6%). Taking into consideration that the etiological importance of CNS has often been neglected, the present investigation confirmed that these microorganisms should not be ignored or classified as mere contaminants.en
dc.description.affiliationUniv Estadual Paulista, Dept Microbiol & Imunol, Inst Biociencias, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Dept Pediat, Fac Med, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Microbiol & Imunol, Inst Biociencias, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Pediat, Fac Med, BR-18618000 Botucatu, SP, Brazil
dc.format.extent661-668
dc.identifier.citationMemorias Do Instituto Oswaldo Cruz. Rio De Janeiro, Rj: Fundaco Oswaldo Cruz, v. 101, n. 6, p. 661-668, 2006.
dc.identifier.issn0074-0276
dc.identifier.urihttp://hdl.handle.net/11449/195861
dc.identifier.wosWOS:000241670700014
dc.language.isoeng
dc.publisherFundaco Oswaldo Cruz
dc.relation.ispartofMemorias Do Instituto Oswaldo Cruz
dc.sourceWeb of Science
dc.subjectcoagulase-negative staphylococci
dc.subjectvirulence factors
dc.subjectslime
dc.subjectenzymes
dc.subjecttoxins
dc.titleStudy of virulence factors in coagulase-negative staphylococci isolated from newbornsen
dc.typeArtigo
dcterms.rightsHolderFundaco Oswaldo Cruz
unesp.author.orcid0000-0001-9079-2723[1]

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