Design and Characterization of Lipid-Surfactant-Based Systems for Enhancing Topical Anti-Inflammatory Activity of Ursolic Acid

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dc.contributor.authorFonseca-Santos, Bruno [UNESP]
dc.contributor.authorAraujo, Giovanna Angeli [UNESP]
dc.contributor.authorFerreira, Paula Scanavez [UNESP]
dc.contributor.authorVictorelli, Francesca Damiani [UNESP]
dc.contributor.authorPironi, Andressa Maria [UNESP]
dc.contributor.authorAraújo, Victor Hugo Sousa [UNESP]
dc.contributor.authorCarvalho, Suzana Gonçalves [UNESP]
dc.contributor.authorChorilli, Marlus [UNESP]
dc.contributor.institutionUniversidade Federal da Bahia (UFBA)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2023-07-29T16:07:10Z
dc.date.available2023-07-29T16:07:10Z
dc.date.issued2023-02-01
dc.description.abstractSkin inflammation is a symptom of many skin diseases, such as eczema, psoriasis, and dermatitis, which cause rashes, redness, heat, or blistering. The use of natural products with anti-inflammatory properties has gained importance in treating these symptoms. Ursolic acid (UA), a promising natural compound that is used to treat skin diseases, exhibits low aqueous solubility, resulting in poor absorption and low bioavailability. Designing topical formulations focuses on providing adequate delivery via application to the skin surface. The aim of this study was to formulate and characterize lipid-surfactant-based systems for the delivery of UA. Microemulsions and liquid crystalline systems (LCs) were characterized by polarized light microscopy (PLM), rheology techniques, and textural and bioadhesive assays. PLM supported the self-assembly of these systems and elucidated their formation. Rheologic examination revealed pseudoplastic and thixotropic behavior appropriate, and assays confirmed the ability of these formulations to adhere to the skin. In vivo studies were performed, and inflammation induced by croton oil was assessed for response to microemulsions and LCs. UA anti-inflammatory activities of ~60% and 50% were demonstrated by two microemulsions and 40% and 35% by two LCs, respectively. These data support the continued development of colloidal systems to deliver UA to ameliorate skin inflammation.en
dc.description.affiliationDepartment of Biotechnology Health Sciences Institute Federal University of Bahia (UFBA), Rector Miguel Calmon Avenue, Campus of Canela, BA
dc.description.affiliationSchool of Pharmaceutical Sciences São Paulo State University—UNESP, SP
dc.description.affiliationUnespSchool of Pharmaceutical Sciences São Paulo State University—UNESP, SP
dc.identifierhttp://dx.doi.org/10.3390/pharmaceutics15020366
dc.identifier.citationPharmaceutics, v. 15, n. 2, 2023.
dc.identifier.doi10.3390/pharmaceutics15020366
dc.identifier.issn1999-4923
dc.identifier.scopus2-s2.0-85149142530
dc.identifier.urihttp://hdl.handle.net/11449/249713
dc.language.isoeng
dc.relation.ispartofPharmaceutics
dc.sourceScopus
dc.subjectbioadhesion
dc.subjectinflammation
dc.subjectskin
dc.subjectsurfactant
dc.subjecttopical product
dc.subjectursolic acid
dc.titleDesign and Characterization of Lipid-Surfactant-Based Systems for Enhancing Topical Anti-Inflammatory Activity of Ursolic Aciden
dc.typeArtigo
unesp.author.orcid0000-0002-4259-0008[1]
unesp.author.orcid0000-0002-0139-457X[7]
unesp.author.orcid0000-0002-6698-0545[8]

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