Performance of Polydioxanone-Based Membrane in Association with 3D-Printed Bioceramic Scaffolds in Bone Regeneration

Página do item simplificado
dc.contributor.authorPitol-Palin, Letícia [UNESP]
dc.contributor.authorFrigério, Paula Buzo [UNESP]
dc.contributor.authorMoura, Juliana [UNESP]
dc.contributor.authorPilatti, Livia
dc.contributor.authorde Oliveira, Letícia Marques Jordão
dc.contributor.authorMatsubara, Elaine Yoshiko
dc.contributor.authorTunchel, Samy
dc.contributor.authorShibli, Jamil Awad
dc.contributor.authorBlay, Alberto
dc.contributor.authorSaska, Sybele
dc.contributor.authorOkamoto, Roberta [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionOdontológicos e Correlatos S.A
dc.contributor.institutionGuarulhos University
dc.date.accessioned2023-07-29T13:36:26Z
dc.date.available2023-07-29T13:36:26Z
dc.date.issued2023-01-01
dc.description.abstractThis study evaluated the bioactivity of 3D-printed β-tricalcium phosphate (β-TCP) scaffolds or hydroxyapatite (HA) scaffolds associated with polydioxanone (PDO) membrane (Plenum® Guide) for guided bone regeneration in rats. Fifty-four rats were divided into three groups (n = 18 animals): autogenous bone + PDO membrane (Auto/PG); 3D-printed β-TCP + PDO membrane (TCP/PG); and 3D-printed HA + PDO membrane (HA/PG). A surgical defect in the parietal bone was made and filled with the respective scaffolds and PDO membrane. The animals were euthanized 7, 30, and 60 days after the surgical procedure for micro-CT, histomorphometric, and immunolabeling analyses. Micro-CT showed an increase in trabecular thickness and a decrease in trabecular separation, even with similar bone volume percentages between TCP/PG and HA/PG vs. Auto/PG. Histometric analysis showed increased bone formation at 30 days in the groups compared to 7 days postoperatively. Immunolabeling analysis showed an increase in proteins related to bone formation at 30 days, and both groups showed a similar immunolabeling pattern. This study concludes that 3D-printed scaffolds associated with PDO membrane (Plenum® Guide) present similar results to autogenous bone for bone regeneration.en
dc.description.affiliationDepartment of Diagnosis and Surgery Araçatuba Dental School São Paulo State University—UNESP
dc.description.affiliationM3 Health Indústria e Comércio de Produtos Médicos Odontológicos e Correlatos S.A
dc.description.affiliationDepartment of Periodontology Dental Research Division Guarulhos University
dc.description.affiliationDepartment of Basic Sciences Araçatuba Dental School São Paulo State University—UNESP
dc.description.affiliationUnespDepartment of Diagnosis and Surgery Araçatuba Dental School São Paulo State University—UNESP
dc.description.affiliationUnespDepartment of Basic Sciences Araçatuba Dental School São Paulo State University—UNESP
dc.identifierhttp://dx.doi.org/10.3390/polym15010031
dc.identifier.citationPolymers, v. 15, n. 1, 2023.
dc.identifier.doi10.3390/polym15010031
dc.identifier.issn2073-4360
dc.identifier.scopus2-s2.0-85146055942
dc.identifier.urihttp://hdl.handle.net/11449/248170
dc.language.isoeng
dc.relation.ispartofPolymers
dc.sourceScopus
dc.subject3D-printed scaffolds
dc.subjectadditive manufacture
dc.subjectbone regeneration
dc.subjectguided tissue regeneration
dc.subjecthydroxyapatite
dc.subjectpolydioxanone
dc.subjectsynthetic polymer
dc.subjectβ-tricalcium phosphate
dc.titlePerformance of Polydioxanone-Based Membrane in Association with 3D-Printed Bioceramic Scaffolds in Bone Regenerationen
dc.typeArtigo
unesp.author.orcid0000-0003-4765-3765[1]
unesp.author.orcid0000-0002-5012-5093[2]
unesp.author.orcid0000-0003-4306-5413[4]
unesp.author.orcid0000-0001-8805-8167[6]
unesp.author.orcid0000-0002-0229-946X[10]
unesp.author.orcid0000-0002-6773-6966[11]

Arquivos

Coleções

Artigos - Ciências Básicas - FOA