Diabete moderado induzido em diferentes fases da vida de ratas Wistar: repercussões na reprodução materna e na freqüência de anomalias fetais

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dc.contributor.advisorDamasceno, Débora Cristina [UNESP]
dc.contributor.authorSaito, Felipe Hiroshi [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-03-23T15:28:09Z
dc.date.available2015-03-23T15:28:09Z
dc.date.issued2009
dc.description.abstractExperimental models are necessary to elucidate pathophysiological mechanisms not yet understood in humans. To evaluate the repercussions of the diabetes, considering two methodologies, on the pregnancy of Wistar rats and on the development of their offspring. In the 1st induction, female offspring were distributed into two experimental groups: Group streptozotocin (STZ, n=67): received the β-cytotoxic agent (100mg STZ/kg body weight - sc) on the 1st day of the life; and Non-diabetic Group (ND, n=14): received the vehicle in a similar time period. In the adult life, the animals were mated. After a positive diagnosis of pregnancy (0), female rats from group STZ presenting with lower glycemia than 120 mg/dL received more 20 mg STZ/kg (ip) at day 7 of pregnancy (2nd induction). The female rats with glycemia higher than 120mg/dL were discarded because they reproduced results already found in the literature. In the mornings of days 0, 7, 14 and 21 of the pregnancy glycemia was determined. At day 21 of pregnancy (at term), the female rats were anesthetized and killed for maternal reproductive performance and fetal development analysis. The data were analyzed using Student-Newman-Keuls, Chi-square and Zero-inflated Poisson (ZIP) Tests (p<0.05). STZ rats presented with increased rates of pre (STZ=22.0%; ND=5.1%) and post-implantation losses (STZ=26.1%; ND=5.7%), reduced rates of fetuses with appropriate weight for gestational age (STZ=66%; ND=93%) and reduced degree of development (ossification sites). Conclusion: Mild diabetes led a negative impact on maternal reproductive performance and caused intrauterine growth restriction and impaired fetal developmenten
dc.description.abstractNão disponívelpt
dc.identifier.aleph000637166
dc.identifier.citationSAITO, Felipe Hiroshi. Diabete moderado induzido em diferentes fases da vida de ratas Wistar: repercussões na reprodução materna e na freqüência de anomalias fetais. 2009. 1 CD-ROM. Trabalho de conclusão de curso (bacharelado - Ciências Biológicas) - Universidade Estadual Paulista, Instituto de Biociências de Botucatu, 2009.
dc.identifier.filesaito_fh_tcc_botib.pdf
dc.identifier.urihttp://hdl.handle.net/11449/120917
dc.language.isopor
dc.publisherUniversidade Estadual Paulista (Unesp)
dc.rights.accessRightsAcesso aberto
dc.sourceAleph
dc.subjectDiabetes na gravidez - Estudos experimentaispt
dc.subjectAnomalias humanaspt
dc.titleDiabete moderado induzido em diferentes fases da vida de ratas Wistar: repercussões na reprodução materna e na freqüência de anomalias fetaispt
dc.typeTrabalho de conclusão de curso
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.undergraduateCiências Biológicas - IBBpt

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