EXPERIMENTAL PARACOCCIDIOIDOMYCOSIS OF HAMSTER INOCULATED IN THE CHEEK POUCH

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dc.contributor.authorArruda, MSP
dc.contributor.authorCoelho, Kunie Iabuki Rabello [UNESP]
dc.contributor.authorMontenegro, M. R.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:21:01Z
dc.date.available2014-05-20T15:21:01Z
dc.date.issued1994-11-01
dc.description.abstractWe compared the granuloma morphology and immune response of hamsters inoculated with Paracoccidioides brasiliensis (Pb) into the cheek pouch, which lacks lymphatic drainage, and into the footpad, which is rich in lymphatics. Our objective was to better understand the modulation of Pb granuloma in an immunocompetent animal inoculated in an immunologically privileged site. The humoral immune response (ELISA) and cell mediated immunity (footpad test) became positive on days 7 and 14, respectively in animals inoculated into footpad and on days 35 and 60 in animals inoculated into the pouch. Typical epithelioid granulomas were observed at both sites on day 14. The number of fungi gradually decreased from the beginning of the experiment in footpad lesions, but only after day 35 in pouch granulomas, when cell mediated immunity was detectable. The results indicate that typical epithelioid paracoccidioidomycotic granulomas may develop in the absence of a detectable immune response; however, they are incapable of controlling fungal reproduction. Lack of lymphatic drainage delays the appearance of a detectable immune response, but with time fungi escape from the pouch, elicit an immune response and reach other organs. Our results further indicate the importance of the lymphatics in the pathogenesis of paracoccidioidomycosis.en
dc.description.affiliationUNIV ESTADUAL PAULISTA,FAC MED,SAO PAULO,BRAZIL
dc.description.affiliationUnespUNIV ESTADUAL PAULISTA,FAC MED,SAO PAULO,BRAZIL
dc.format.extent67-73
dc.identifierhttp://dx.doi.org/10.1007/BF01103011
dc.identifier.citationMycopathologia. Dordrecht: Kluwer Academic Publ, v. 128, n. 2, p. 67-73, 1994.
dc.identifier.doi10.1007/BF01103011
dc.identifier.issn0301-486X
dc.identifier.urihttp://hdl.handle.net/11449/32202
dc.identifier.wosWOS:A1994QY29000002
dc.language.isoeng
dc.publisherKluwer Academic Publ
dc.relation.ispartofMycopathologia
dc.relation.ispartofjcr1.476
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectCHEEK POUCHpt
dc.subjectGRANULOMApt
dc.subjectHAMSTERpt
dc.subjectPARACOCCIDIOIDOMYCOSISpt
dc.titleEXPERIMENTAL PARACOCCIDIOIDOMYCOSIS OF HAMSTER INOCULATED IN THE CHEEK POUCHen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights
dcterms.rightsHolderKluwer Academic Publ
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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