Expression of Ki-67 antigen and caspase-3 protein in benign lesions and esophageal carcinoma
| dc.contributor.author | Bellini, Marilanda Ferreira [UNESP] | |
| dc.contributor.author | Cury, Patrícia Maluf | |
| dc.contributor.author | Silva, Ana Elizabete [UNESP] | |
| dc.contributor.institution | Universidade Estadual Paulista (UNESP) | |
| dc.contributor.institution | Medical School | |
| dc.date.accessioned | 2022-04-29T08:44:20Z | |
| dc.date.available | 2022-04-29T08:44:20Z | |
| dc.date.issued | 2010-07-01 | |
| dc.description.abstract | Background: The present study aimed to evaluate apoptosis and cell proliferation alterations in esophageal benign lesions in comparison to esophageal carcinomas. Materials and Methods: Immunohistochemistry was performed for caspase-3 protein (CPP32) and Ki-67 antigen expression in the esophageal mucosa from patients with Chagas disease (CD) with and without megaesophagus (CM), chronic esophagitis (CE), esophageal carcinoma (ESCC) and in normal mucosa (NM). Results: The Ki-67 labeling index (LI) was similar in all groups (range: 30%-48%), having no statistically significant difference among the groups. Positive CPP32 immunostaining was observed with similar frequency in the CD (30.8%), CM (30.4%) and CE (34.8%) groups, but it was increased in the ESCC group (555%); however, it was not statistically different from the other groups. No associations among the levels of CPP32 and Ki-67 expression were observed in the various groups, neither among parameters such as age, gender or alcohol and tobacco consumption. Conclusion: There were no evident changes in cell proliferation and apoptosis in benign lesions studied. | en |
| dc.description.affiliation | Department of Biology UNESP São Paulo State University, SP | |
| dc.description.affiliation | Department of Pathology FAMERP Medical School, Säo José do Rio Preto, SP | |
| dc.description.affiliationUnesp | Department of Biology UNESP São Paulo State University, SP | |
| dc.format.extent | 2845-2849 | |
| dc.identifier.citation | Anticancer Research, v. 30, n. 7, p. 2845-2849, 2010. | |
| dc.identifier.issn | 0250-7005 | |
| dc.identifier.scopus | 2-s2.0-77955784934 | |
| dc.identifier.uri | http://hdl.handle.net/11449/231245 | |
| dc.language.iso | eng | |
| dc.relation.ispartof | Anticancer Research | |
| dc.source | Scopus | |
| dc.subject | Chagasic megaesophagus | |
| dc.subject | Chronic esophagitis | |
| dc.subject | CPP32 | |
| dc.subject | Esophageal squamous cell carcinoma | |
| dc.subject | Ki-67 | |
| dc.title | Expression of Ki-67 antigen and caspase-3 protein in benign lesions and esophageal carcinoma | en |
| dc.type | Artigo |