Clinical trials in cardiac xenotransplantation: Are we ready to overcome barriers?

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dc.contributor.authorGarcia, Leonardo Rufino [UNESP]
dc.contributor.authorBrito, Flavio de Souza [UNESP]
dc.contributor.authorFelicio, Marcello Laneza [UNESP]
dc.contributor.authorGarzesi, André Monti [UNESP]
dc.contributor.authorTardivo, Márcia Terezinha [UNESP]
dc.contributor.authorPolegato, Bertha Furlan [UNESP]
dc.contributor.authorMinicucci, Marcos Ferreira [UNESP]
dc.contributor.authorZornoff, Leonardo Antônio Mamede [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-05-01T06:31:29Z
dc.date.available2022-05-01T06:31:29Z
dc.date.issued2021-10-01
dc.description.abstractHeart allotransplantation has become one of the methods of choice in the treatment of severe heart failure. In the face of its difficulties, such as the unmet balance between organ supply and demand, the use of xenotransplantation (XTx) might be an attractive option shortly, even more with the ongoing progress achieved regarding the avoidance of hyperacute rejection and primary organ disfunction, maintenance of xenograft function and control of xenograft growth. To make possible this translational challenge, some points must be taken into account indeed, and they are the equipoise of human benefit and animal suffering, the risk of unknown infections, a well prepared informed consent, ethical and religious beliefs, and the role of cardiac XTx in a ventricular assistance device era.en
dc.description.affiliationDepartment of Surgery Universidade Estadual Paulista—UNESP SP
dc.description.affiliationDepartment of Internal Medicine Universidade Estadual Paulista–UNESP SP
dc.description.affiliationUnespDepartment of Surgery Universidade Estadual Paulista—UNESP SP
dc.description.affiliationUnespDepartment of Internal Medicine Universidade Estadual Paulista–UNESP SP
dc.format.extent3796-3801
dc.identifierhttp://dx.doi.org/10.1111/jocs.15747
dc.identifier.citationJournal of Cardiac Surgery, v. 36, n. 10, p. 3796-3801, 2021.
dc.identifier.doi10.1111/jocs.15747
dc.identifier.issn1540-8191
dc.identifier.issn0886-0440
dc.identifier.scopus2-s2.0-85111167409
dc.identifier.urihttp://hdl.handle.net/11449/233308
dc.language.isoeng
dc.relation.ispartofJournal of Cardiac Surgery
dc.sourceScopus
dc.subjectcardiovascular pathology
dc.subjectcardiovascular research
dc.subjectclinical review
dc.subjecttransplant
dc.titleClinical trials in cardiac xenotransplantation: Are we ready to overcome barriers?en
dc.typeResenha
unesp.author.orcid0000-0002-8280-471X[1]

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