Dimerization of antimicrobial peptides: A promising strategy to enhance antimicrobial peptide activity

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dc.contributor.authorLorenzon, Esteban N.
dc.contributor.authorPiccoli, Julia P. [UNESP]
dc.contributor.authorSantos-Filho, Norival A. [UNESP]
dc.contributor.authorCilli, Eduardo M. [UNESP]
dc.contributor.institutionUniversidade Federal de Jataí
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2019-10-06T16:19:43Z
dc.date.available2019-10-06T16:19:43Z
dc.date.issued2019-01-01
dc.description.abstractAntimicrobial resistance is a global health problem with strong social and economic impacts. The development of new antimicrobial agents is considered an urgent challenge. In this regard, Antimicrobial Peptides (AMPs) appear to be novel candidates to overcome this problem. The mechanism of action of AMPs involves intracellular targets and membrane disruption. Although the exact mechanism of action of AMPs remains controversial, most AMPs act through membrane disruption of the target cell. Several strategies have been used to improve AMP activity, such as peptide dimerization. In this review, we focus on AMP dimerization, showing many examples of dimerized peptides and their effects on biological activity. Although more studies are necessary to elucidate the relationship between peptide properties and the dimerization effect on antimicrobial activity, dimerization constitutes a promising strategy to improve the effectiveness of AMPs.en
dc.description.affiliationUnidade Acadêmica Especial da Saúde Universidade Federal de Jataí
dc.description.affiliationInstituto de Química UNESP- Universidade Estadual Paulista
dc.description.affiliationUNESP- Universidade Estadual Paulista Campus Experimental de Registro
dc.description.affiliationUnespInstituto de Química UNESP- Universidade Estadual Paulista
dc.description.affiliationUnespUNESP- Universidade Estadual Paulista Campus Experimental de Registro
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 12/15346-7
dc.description.sponsorshipIdFAPESP: 13/07600-3
dc.format.extent98-107
dc.identifierhttp://dx.doi.org/10.2174/0929866526666190102125304
dc.identifier.citationProtein and Peptide Letters, v. 26, n. 2, p. 98-107, 2019.
dc.identifier.doi10.2174/0929866526666190102125304
dc.identifier.issn1875-5305
dc.identifier.issn0929-8665
dc.identifier.scopus2-s2.0-85062429908
dc.identifier.urihttp://hdl.handle.net/11449/188802
dc.language.isoeng
dc.relation.ispartofProtein and Peptide Letters
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectAntimicrobial
dc.subjectAntimicrobial peptides (amps)
dc.subjectDimerization
dc.subjectMechanism of action
dc.subjectMembrane
dc.subjectPeptide
dc.titleDimerization of antimicrobial peptides: A promising strategy to enhance antimicrobial peptide activityen
dc.typeResenha

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Artigos - Engenharia Agronômica - Registro