Avaliação de mediadores da resposta inflamatória na interface materno-fetal: Estudo in vitro de infecção bacteriana, isolada ou em combinação com Mycoplasma hominis, em células amnióticas epiteliais imortalizadas
dc.contributor.advisor | Silva, Márcia Guimarães da [UNESP] | |
dc.contributor.author | Cursino, Geovanna Cristofani [UNESP] | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.date.accessioned | 2022-12-19T15:03:38Z | |
dc.date.available | 2022-12-19T15:03:38Z | |
dc.date.issued | 2022-11-21 | |
dc.description.abstract | To evaluate the mediators of the inflammatory response, in an in vitro model, of immortalized epithelial amniotic cells (hFM-AECs) challenged by different bacterial species, alone and in combinations with Mycoplasma hominis, and the interference of this stimulus on the epithelial-mesenchymal transition. In vitro assay with hFM-AECs challenged with different species were performed in diferente moments. Supernatants were collected for quantification of IL-1β, IL-6, IL-8, IL-10, IL-13, GM-CSF, TNF-α, HBD-1, HBD-2 and HBD-3 by ELISA. For analyses of EMT, the cell shape index was applied. The data were subjected to a mixed effects model combined with parametric bootstrapping.One Way ANOVA and paired T-test were used for the EMT analysis. (a) Elevated levels of IL-6, IL-8, GM-CSF and HBD-1 were detected in relation to the reference when stimulated with Fusobacterium nucleatum, alone or in combination with M. hominis; (b) IL-13 levels were decreased in relation to the reference after stimulation with F. nucleatum, Bacteroides fragilis, Peptostreptococcus anaerobius and Streptococcus agalactiae alone and in combination with M. hominis; (c) Different isolates or combination with M. hominis stimulated EMT. F. nucleatum alone or in combination with M. hominis, have an important capacity to induce a characteristic inflammatory signature. Bacterial combinations stimulate EMT. | en |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | |
dc.identifier.capes | 33004064056P5 | |
dc.identifier.uri | http://hdl.handle.net/11449/238299 | |
dc.language.iso | eng | |
dc.publisher | Universidade Estadual Paulista (Unesp) | |
dc.rights.accessRights | Acesso restrito | |
dc.subject | In vitro study | en |
dc.subject | Immortalized amnion epithelial cells (hFM-AECs) | en |
dc.subject | Adverse pregnancy outcome | en |
dc.subject | Genital mycoplasmas | en |
dc.subject | Polybacterial infection | en |
dc.subject | Epithelial-mesenchymal transition (EMT) | en |
dc.title | Avaliação de mediadores da resposta inflamatória na interface materno-fetal: Estudo in vitro de infecção bacteriana, isolada ou em combinação com Mycoplasma hominis, em células amnióticas epiteliais imortalizadas | pt |
dc.title.alternative | Evaluation of inflammatory response mediators at maternal-fetal interface: In vitro study of bacterial infection, isolated or in combination with Mycoplasma hominis, in immortalized amniotic epithelial cells | en |
dc.type | Dissertação de mestrado | |
unesp.campus | Universidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatu | pt |
unesp.embargo | 12 meses após a data da defesa | pt |
unesp.examinationboard.type | Banca pública | pt |
unesp.graduateProgram | Patologia - FMB | pt |
unesp.knowledgeArea | Patologia | pt |
unesp.researchArea | Patologia Clínica - Gestação | pt |
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