Synthesis, characterization and biological analysis of the complex [VO(Hdhp)(2)] (H(2)dhp=2,3-dihydroxypyridine)

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dc.contributor.authorPepato, Maria Teresa [UNESP]
dc.contributor.authorAlberconi, Mayara F. [UNESP]
dc.contributor.authorda Rocha, Michelle C. [UNESP]
dc.contributor.authorVendramini, Regina Célia [UNESP]
dc.contributor.authorBrunetti, Iguatemy Lourenço [UNESP]
dc.contributor.authorBatista, Alzir A.
dc.contributor.authorde Souza, Elizeu J.
dc.contributor.authorGarcia, Edgardo
dc.contributor.authorDeflon, Victor M.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.contributor.institutionUniversidade de Brasília (UnB)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-20T13:23:55Z
dc.date.available2014-05-20T13:23:55Z
dc.date.issued2008-04-01
dc.description.abstractA new vanadium (IV) complex with the monoanion of 2,3-dihydroxypyridine (H(2)dhp), or 3-hydroxy-2(1H)-pyridone, was synthesized, characterized by physicochemical techniques and tested biologically. The EPR data for the [VO(Hdhp)(2)] complex in DMF are: g(x) = 1.9768, g(y) = 1.9768 and g(z) = 1.9390; A values (10(-4) cm(-1)): A(x), 59.4; A(y//), 59.4; A(z), 171.0. The vV=O band in the IR spectrum of the complex is at 986 cm(-1). The complex is paramagnetic, with mu(eff) = 1.65 BM (d(1), spin-only) at 25 degrees C. The irreversible oxidation process [V(V)/V(IV)] of the [VO(Hdhp)(2)] complex, as revealed in a cyclic voltammogram, occurs at 876 mV. The calculated molecular structure of [VO(Hdhp)(2)] shows the vanadium(IV) center in a distorted square pyramidal environment, with the oxo ligand in the apical position and the oxygen donor atoms of the Hdhp ligands in the basal positions. The ability of [VO(Hdhp)(2)] to mimic insulin, and its toxicity to hepato-biliary functions, were investigated in streptozotocin-induced diabetic rats and it was concluded that the length of treatment and the amount of [VO(Hdhp)(2)] administered were effective in reducing experimental diabetes.en
dc.description.affiliationUniv Estadual Paulista, Fac Ciencias Farmaceut, Dept Aanl Clin, Araraquara, SP, Brazil
dc.description.affiliationUniversidade Federal de São Carlos (UFSCar), Dept Quim, BR-13560 São Carlos, SP, Brazil
dc.description.affiliationUniversidade de Brasilia (UnB), Inst Quim, Brasilia, DF, Brazil
dc.description.affiliationUniv São Paulo, Inst Quim, São Carlos, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciencias Farmaceut, Dept Aanl Clin, Araraquara, SP, Brazil
dc.format.extent301-309
dc.identifierhttp://dx.doi.org/10.1007/s11243-007-9003-5
dc.identifier.citationTransition Metal Chemistry. Dordrecht: Springer, v. 33, n. 3, p. 301-309, 2008.
dc.identifier.doi10.1007/s11243-007-9003-5
dc.identifier.issn0340-4285
dc.identifier.lattes7641979287850489
dc.identifier.urihttp://hdl.handle.net/11449/7307
dc.identifier.wosWOS:000254850500005
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofTransition Metal Chemistry
dc.relation.ispartofjcr1.261
dc.relation.ispartofsjr0,306
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleSynthesis, characterization and biological analysis of the complex [VO(Hdhp)(2)] (H(2)dhp=2,3-dihydroxypyridine)en
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer
unesp.author.lattes7641979287850489
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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Artigos - Análises Clínicas - FCFAR