Antifungal Compounds Produced by Colletotrichum gloeosporioides, an Endophytic Fungus from Michelia champaca

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dc.contributor.authorChapla, Vanessa Mara [UNESP]
dc.contributor.authorZeraik, Maria Luiza [UNESP]
dc.contributor.authorLeptokarydis, Ioanis Hcristos [UNESP]
dc.contributor.authorSilva, Geraldo Humberto
dc.contributor.authorBolzani, Vanderlan da Silva [UNESP]
dc.contributor.authorYoung, Maria Claudia M.
dc.contributor.authorPfenning, Ludwig Heinrich
dc.contributor.authorAraújo, Angela Regina [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de Viçosa (UFV)
dc.contributor.institutionNucleo Pesquisa Fisiol & Bioquim
dc.contributor.institutionUniversidade Federal de Lavras (UFLA)
dc.date.accessioned2015-03-18T15:56:21Z
dc.date.available2015-03-18T15:56:21Z
dc.date.issued2014-11-01
dc.description.abstractIn this study, eight endophytic fungi were isolated from the leaves, stems and roots of Michelia champaca. The isolates were screened and evaluated for their antifungal, anticancer and acetylcholinesterase (AChE) inhibitory activities. All of the extracts exhibited potent activity against two evaluated phytopathogenic fungi. Chemical investigation of EtOAc extracts of the endophytic fungus Colletotrichum gloeosporioides resulted in the isolation of one new compound, 2-phenylethyl 1H-indol-3-yl-acetate (1), and seven known compounds: uracil (2), cyclo-(S*-Pro-S*-Tyr) (3), cyclo-(S*-Pro-S*-Val) (4), 2(2-aminophenyl)acetic acid (5), 2(4-hydroxyphenyl) acetic acid (6), 4-hydroxy-benzamide (7) and 2(2-hydroxyphenyl) acetic acid (8). All of the compound structures were elucidated using 1D and 2D NMR and MS analyses. The antifungal and AChE inhibitory activities of compounds 1-8 were evaluated in vitro. Compound 1 exhibited promising activity against Cladosporium cladosporioides and C. sphaerospermum that was comparable to that of the positive control nystatin.en
dc.description.affiliationUniv Estadual Paulista, NuBBE Nucleo Bioensaios Biossintese & Ecofisiol P, Dept Quim Organ, Inst Quim,UNESP, BR-14800900 Araraquara, SP, Brazil
dc.description.affiliationUniv Fed Vicosa, Inst Ciencias Exatas, BR-38810000 Vicosa, MG, Brazil
dc.description.affiliationNucleo Pesquisa Fisiol & Bioquim, Inst Bot, BR-04301902 Sao Paulo, Brazil
dc.description.affiliationUniv Fed Lavras, Dept Fitopatol, BR-37200000 Lavras, MG, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, NuBBE Nucleo Bioensaios Biossintese & Ecofisiol P, Dept Quim Organ, Inst Quim,UNESP, BR-14800900 Araraquara, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdFAPESP: 03/02176-7
dc.description.sponsorshipIdFAPESP: 10/52327-5
dc.description.sponsorshipIdFAPESP: 13/07600-3
dc.description.sponsorshipIdFAPESP: 11/03017-6
dc.format.extent19243-19252
dc.identifierhttp://dx.doi.org/10.3390/molecules191119243
dc.identifier.citationMolecules. Basel: Mdpi Ag, v. 19, n. 11, p. 19243-19252, 2014.
dc.identifier.doi10.3390/molecules191119243
dc.identifier.fileWOS000345564300128.pdf
dc.identifier.issn1420-3049
dc.identifier.lattes4484083685251673
dc.identifier.lattes0037579054083160
dc.identifier.orcid0000-0001-7616-9652
dc.identifier.urihttp://hdl.handle.net/11449/117521
dc.identifier.wosWOS:000345564300128
dc.language.isoeng
dc.publisherMdpi Ag
dc.relation.ispartofMolecules
dc.relation.ispartofjcr3.098
dc.relation.ispartofsjr0,855
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectColletotrichum gloeosporioidesen
dc.subjectendophytic fungusen
dc.subjectantifungal activityen
dc.titleAntifungal Compounds Produced by Colletotrichum gloeosporioides, an Endophytic Fungus from Michelia champacaen
dc.typeArtigo
dcterms.rightsHolderMdpi Ag
unesp.author.lattes4484083685251673
unesp.author.lattes0037579054083160[8]
unesp.author.orcid0000-0001-7616-9652[8]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt

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