Endocrine Disruptors and Hypothalamic Sexual Differentiation

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dc.contributor.authorPereira, Oduvaldo C. M. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:20:58Z
dc.date.available2014-05-27T11:20:58Z
dc.date.issued2003-12-01
dc.description.abstractThe so-called endocrine disruptors have been described as compounds which interfere with the estrogen action in their receptors and may exert a crucial role in the development of the reproductive tract and in the brain sexual differentiation. Thus, conducts and/or exposure to these drugs in the perinatal period that apparently do not endanger the neonate may cause side effects. During embrionary development, the gonads, through discharge of a small quantity of reproductive hormones, will guarantee the phenotype of male or female at birth, as well as actuate in specific areas sexual differentiation of the central nervous system. Several experimental models have shown an interference of drugs acting as endocrine disruptors in hypothalamic sexual differentiation. Thus, reproductive function is impaired by exposure to estrogen in the perinatal life of rats and the mechanisms involved in this effect are distinct for males and females. Perinatal exposure to drugs which may be considered endocrine disrupters may induce an incomplete masculinization and defeminization of the central nervous system. Alterations in these processes, if present, generally are perceived only at puberty or adult reproductive life. These later alterations may include anomalies in the process of fertility or in sexual behavior.en
dc.description.affiliationInstituto de Biociências UNESP
dc.description.affiliationDepartamento de Farmacologia Instituto de Biociências UNESP, 18618-000, Botucatu, SP
dc.description.affiliationUnespInstituto de Biociências UNESP
dc.description.affiliationUnespDepartamento de Farmacologia Instituto de Biociências UNESP, 18618-000, Botucatu, SP
dc.format.extent87-94
dc.identifierhttp://dx.doi.org/10.5016/1806-8774.2003v5p87
dc.identifier.citationAnnual Review of Biomedical Sciences, v. 5, p. 87-94.
dc.identifier.doi10.5016/1806-8774.2003v5p87
dc.identifier.file2-s2.0-1942424747.pdf
dc.identifier.issn1806-8774
dc.identifier.scopus2-s2.0-1942424747
dc.identifier.urihttp://hdl.handle.net/11449/67526
dc.language.isoeng
dc.relation.ispartofAnnual Review of Biomedical Sciences
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectBrain sexual differentiation
dc.subjectEndocrine disruptors
dc.subjectEstrogen
dc.subjectFertility
dc.subjectReproductive function
dc.subjectSexual behavior
dc.subjectantiandrogen
dc.subjectendocrine disruptor
dc.subjectenvironmental chemical
dc.subjectestrogen
dc.subjectestrogen receptor
dc.subjectunclassified drug
dc.subjectxenobiotic agent
dc.subjectembryo development
dc.subjectestrogen activity
dc.subjectfertility
dc.subjectgonad
dc.subjecthypothalamus
dc.subjectimmobilization stress
dc.subjectnonhuman
dc.subjectperinatal period
dc.subjectreproduction
dc.subjectsex differentiation
dc.subjectsexual behavior
dc.subjectshort survey
dc.subjectvirilization
dc.titleEndocrine Disruptors and Hypothalamic Sexual Differentiationen
dc.typeArtigo
dcterms.licensehttp://arbs.biblioteca.unesp.br/index.php/arbs/about/submissions#copyrightNotice
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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