Variants at the ASIP locus contribute to coat color darkening in Nellore cattle

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dc.contributor.authorTrigo, Beatriz B. [UNESP]
dc.contributor.authorUtsunomiya, Adam T. H.
dc.contributor.authorFortunato, Alvaro A. A. D. [UNESP]
dc.contributor.authorMilanesi, Marco [UNESP]
dc.contributor.authorTorrecilha, Rafaela B. P.
dc.contributor.authorLamb, Harrison
dc.contributor.authorNguyen, Loan
dc.contributor.authorRoss, Elizabeth M.
dc.contributor.authorHayes, Ben
dc.contributor.authorPadula, Rômulo C. M.
dc.contributor.authorSussai, Thayla S.
dc.contributor.authorZavarez, Ludmilla B.
dc.contributor.authorCipriano, Rafael S.
dc.contributor.authorCaminhas, Maria M. T. [UNESP]
dc.contributor.authorLopes, Flavia L. [UNESP]
dc.contributor.authorPelle, Cassiano
dc.contributor.authorLeeb, Tosso
dc.contributor.authorBannasch, Danika
dc.contributor.authorBickhart, Derek
dc.contributor.authorSmith, Timothy P. L.
dc.contributor.authorSonstegard, Tad S.
dc.contributor.authorGarcia, José F. [UNESP]
dc.contributor.authorUtsunomiya, Yuri T. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionInternational Atomic Energy Agency (IAEA) Collaborating Centre On Animal Genomics and Bioinformatics
dc.contributor.institutionAgroPartners Consulting
dc.contributor.institutionPersonal-PEC
dc.contributor.institutionThe University of Queensland
dc.contributor.institutionCentro Universitário Católico Salesiano
dc.contributor.institutionCRV Lagoa
dc.contributor.institutionUniversity of Bern
dc.contributor.institutionUniversity of California
dc.contributor.institutionUSDA-ARS
dc.contributor.institutionRecombinetics Inc.
dc.date.accessioned2021-06-25T10:58:52Z
dc.date.available2021-06-25T10:58:52Z
dc.date.issued2021-12-01
dc.description.abstractBackground: Nellore cattle (Bos indicus) are well-known for their adaptation to warm and humid environments. Hair length and coat color may impact heat tolerance. The Nellore breed has been strongly selected for white coat, but bulls generally exhibit darker hair ranging from light grey to black on the head, neck, hump, and knees. Given the potential contribution of coat color variation to the adaptation of cattle populations to tropical and sub-tropical environments, our aim was to map positional and functional candidate genetic variants associated with darkness of hair coat (DHC) in Nellore bulls. Results: We performed a genome-wide association study (GWAS) for DHC using data from 432 Nellore bulls that were genotyped for more than 777 k single nucleotide polymorphism (SNP) markers. A single major association signal was detected in the vicinity of the agouti signaling protein gene (ASIP). The analysis of whole-genome sequence (WGS) data from 21 bulls revealed functional variants that are associated with DHC, including a structural rearrangement involving ASIP (ASIP-SV1). We further characterized this structural variant using Oxford Nanopore sequencing data from 13 Australian Brahman heifers, which share ancestry with Nellore cattle; we found that this variant originates from a 1155-bp deletion followed by an insertion of a transposable element of more than 150 bp that may impact the recruitment of ASIP non-coding exons. Conclusions: Our results indicate that the variant ASIP sequence causes darker coat pigmentation on specific parts of the body, most likely through a decreased expression of ASIP and consequently an increased production of eumelanin.en
dc.description.affiliationSchool of Veterinary Medicine Araçatuba Department of Production and Animal Health São Paulo State University (Unesp)
dc.description.affiliationInternational Atomic Energy Agency (IAEA) Collaborating Centre On Animal Genomics and Bioinformatics
dc.description.affiliationAgroPartners Consulting, R. Floriano Peixoto, 120-Sala 43a-Centro
dc.description.affiliationPersonal-PEC, R. Sebastião Lima, 1336-Centro
dc.description.affiliationCentre for Animal Science Queensland Alliance for Agriculture and Food Innovation The University of Queensland
dc.description.affiliationCentro Universitário Católico Salesiano
dc.description.affiliationCRV Lagoa
dc.description.affiliationInstitute of Genetics Vetsuisse-Faculty University of Bern, Bremgartenstrasse 109A
dc.description.affiliationDermfocus University of Bern, Bremgartenstrasse 109A
dc.description.affiliationDepartment of Population Health and Reproduction School of Veterinary Medicine University of California
dc.description.affiliationDairy Forage Research Center USDA-ARS, 1925 Linden Drive
dc.description.affiliationUS. Meat Animal Research Center USDA-ARS, 844 Road 313
dc.description.affiliationRecombinetics Inc.
dc.description.affiliationSchool of Agriculture and Veterinarian Sciences Jaboticabal Department of Preventive Veterinary Medicine and Animal Reproduction São Paulo State University (Unesp)
dc.description.affiliationUnespSchool of Veterinary Medicine Araçatuba Department of Production and Animal Health São Paulo State University (Unesp)
dc.description.affiliationUnespSchool of Agriculture and Veterinarian Sciences Jaboticabal Department of Preventive Veterinary Medicine and Animal Reproduction São Paulo State University (Unesp)
dc.description.sponsorshipMeat and Livestock Australia
dc.description.sponsorshipIdMeat and Livestock Australia: B.STU.2001
dc.description.sponsorshipIdMeat and Livestock Australia: L.GEN.1808
dc.description.sponsorshipIdMeat and Livestock Australia: P.PSH.0833
dc.identifierhttp://dx.doi.org/10.1186/s12711-021-00633-2
dc.identifier.citationGenetics Selection Evolution, v. 53, n. 1, 2021.
dc.identifier.doi10.1186/s12711-021-00633-2
dc.identifier.issn1297-9686
dc.identifier.issn0999-193X
dc.identifier.scopus2-s2.0-85104958941
dc.identifier.urihttp://hdl.handle.net/11449/207661
dc.language.isoeng
dc.relation.ispartofGenetics Selection Evolution
dc.sourceScopus
dc.titleVariants at the ASIP locus contribute to coat color darkening in Nellore cattleen
dc.typeArtigo
unesp.author.orcid0000-0002-6526-8337[23]
unesp.departmentMedicina Veterinária Preventiva e Reprodução Animal - FCAVpt

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Jaboticabal - FCAV - Faculdade de Ciências Agrárias e Veterinárias