Crotoxin-induced behavioral effects in rats

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dc.contributor.authorMoreira, E. G.
dc.contributor.authorNascimento, N.
dc.contributor.authorRosa, GJM
dc.contributor.authorRogero, JR
dc.contributor.authorVassilieff, V. S.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionInstituto de Pesquisas Energéticas e Nucleares (IPEN)
dc.date.accessioned2014-05-20T15:23:52Z
dc.date.available2014-05-20T15:23:52Z
dc.date.issued1996-05-01
dc.description.abstractCrotoxin is the major component of Crotalus durissus terrificus venom. In view of the presence of high-affinity specific binding sites for crotoxin in the brain, the objective of this work was to investigate whether crotoxin induces behavioral effects in the open-field and hole-board tests. Adult male Wistar rats (180-220 g) treated with crotoxin, 100, 250 and 500 mu g/kg, ip, administered 2 h before the test, presented statistically significant behavioral alterations (ANOVA for one-way classification complemented with Dunnet test, P<0.05). In the open-field test, 250 and 500 mu g/kg of crotoxin increased freezing (from 3.22 sec to 10.75 sec and 11.2 sec) and grooming (from 13.44 sec to 22.75 sec and 21.22 sec) and decreased ambulation (from 64.8 to 39.38 and 45.8). The dose of 500 mu g/kg also decreased rearing (from 24.9 to 17.5). In the hole-board test, 500 mu g/kg of crotoxin decreased head-dip count (from 6.33 to 4.00). All the crotoxin-induced behavioral effects were antagonized by an anxiolytic dose of diazepam (1.5 mg/kg, ip, 30 min before the tests). These results show that crotoxin reduced open-field activity and exploratory behavior as well. We suggest that these effects express an increased emotional state induced by this toxin.en
dc.description.affiliationUNIV ESTADUAL PAULISTA, DEPT FARMACOL, BR-18618000 BOTUCATU, SP, BRAZIL
dc.description.affiliationUNIV ESTADUAL PAULISTA, DEPT BIOESTATIST, BR-18618000 BOTUCATU, SP, BRAZIL
dc.description.affiliationIPEN CNEN SP, DIV RADIOBIOL, BR-05508000 SAO PAULO, SP, BRAZIL
dc.description.affiliationUnespUNIV ESTADUAL PAULISTA, DEPT FARMACOL, BR-18618000 BOTUCATU, SP, BRAZIL
dc.description.affiliationUnespUNIV ESTADUAL PAULISTA, DEPT BIOESTATIST, BR-18618000 BOTUCATU, SP, BRAZIL
dc.format.extent629-632
dc.identifierhttp://www.scielo.br/scielo.php?script=sci_issues&pid=0100-879X&lng=en&nrm=iso
dc.identifier.citationBrazilian Journal of Medical and Biological Research. São Paulo: Associação Bras Divulg Cientifica, v. 29, n. 5, p. 629-632, 1996.
dc.identifier.issn0100-879X
dc.identifier.urihttp://hdl.handle.net/11449/34566
dc.identifier.wosWOS:A1996UL39200012
dc.language.isoeng
dc.publisherAssociação Brasileira de Divulgação Científica (ABRADIC)
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.relation.ispartofjcr1.492
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectcrotoxinpt
dc.subjectCrotalus durissus terrificus venompt
dc.subjectemotionalitypt
dc.subjectopen-fieldpt
dc.subjecthole-boardpt
dc.titleCrotoxin-induced behavioral effects in ratsen
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/bjmbr/iaboutj.htm
dcterms.rightsHolderAssociação Bras Divulg Cientifica
unesp.author.orcid0000-0001-9172-6461[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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