Neuronal Circuits Involved in Osmotic Challenges

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dc.contributor.authorSantos Moreira, M. C. dos
dc.contributor.authorNaves, L. M.
dc.contributor.authorMarques, S. M.
dc.contributor.authorSilva, E. F.
dc.contributor.authorRebelo, A. C. S.
dc.contributor.authorColombari, E. [UNESP]
dc.contributor.authorPedrino, G. R.
dc.contributor.institutionUniversidade Federal de Goiás (UFG)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-11-26T17:39:45Z
dc.date.available2018-11-26T17:39:45Z
dc.date.issued2017-01-01
dc.description.abstractThe maintenance of plasma sodium concentration within a narrow limit is crucial to life. When it differs from normal physiological patterns, several mechanisms are activated in order to restore body fluid homeostasis. Such mechanisms may be vegetative and/or behavioral, and several regions of the central nervous system (CNS) are involved in their triggering. Some of these are responsible for sensory pathways that perceive a disturbance of the body fluid homeostasis and transmit information to other regions. These regions, in turn, initiate adequate adjustments in order to restore homeostasis. The main cardiovascular and autonomic responses to a change in plasma sodium concentration are: i) changes in arterial blood pressure and heart rate; ii) changes in sympathetic activity to the renal system in order to ensure adequate renal sodium excretion/absorption, and iii) the secretion of compounds involved in sodium ion homeostasis (ANP, Ang-II, and ADH, for example). Due to their cardiovascular effects, hypertonic saline solutions have been used to promote resuscitation in hemorrhagic patients, thereby increasing survival rates following trauma. In the present review, we expose and discuss the role of several CNS regions involved in body fluid homeostasis and the effects of acute and chronic hyperosmotic challenges.en
dc.description.affiliationUniv Fed Goias, Ctr Neurosci & Cardiovasc Res, Goiania, Go, Brazil
dc.description.affiliationUniv Estadual Paulista, Dept Physiol & Pathol, Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Physiol & Pathol, Araraquara, SP, Brazil
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Goias (FAPEG)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFundacao de Amparo a Pesquisa do Estado de Goias (FAPEG): 2012/0055431086
dc.description.sponsorshipIdFundacao de Amparo a Pesquisa do Estado de Goias (FAPEG): 2009/10267000352
dc.description.sponsorshipIdCNPq: 477832/2010-5
dc.description.sponsorshipIdCNPq: 483411/2012-4
dc.description.sponsorshipIdCNPq: 447496/2014-0
dc.description.sponsorshipIdCNPq: 309989/2016-7
dc.format.extent411-423
dc.identifier.citationPhysiological Research. Prague 4: Acad Sciences Czech Republic, Inst Physiology, v. 66, n. 3, p. 411-423, 2017.
dc.identifier.fileWOS000405692500005.pdf
dc.identifier.issn0862-8408
dc.identifier.urihttp://hdl.handle.net/11449/163010
dc.identifier.wosWOS:000405692500005
dc.language.isoeng
dc.publisherAcad Sciences Czech Republic, Inst Physiology
dc.relation.ispartofPhysiological Research
dc.relation.ispartofsjr0,568
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectBody fluid homeostasis
dc.subjectOsmosensory areas
dc.subjectAcute hyperosmotic challenge
dc.subjectChronic hyperosmotic challenge
dc.titleNeuronal Circuits Involved in Osmotic Challengesen
dc.typeResenha
dcterms.rightsHolderAcad Sciences Czech Republic, Inst Physiology
unesp.author.lattes4544450092427426[6]
unesp.author.orcid0000-0002-1395-4036[6]

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