Effects caused by the spinal administration of ketamine S (+) 5% with no preservatives, using a single puncture, and located on the spinal cord and meninges in rabbits

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dc.contributor.authorLima Filho, José Admirço
dc.contributor.authorFin, Natalia Castro
dc.contributor.authorValerini, Felipe Gilberto
dc.contributor.authorMachado, Vania Maria de Vasconcelos [UNESP]
dc.contributor.authorMarques, Mariangela Ester
dc.contributor.authorMiot, Hélio
dc.contributor.authorLima, Lais Helena Navarro E
dc.contributor.authorGanen, Eliana Marisa
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-10-01T13:08:39Z
dc.date.available2014-10-01T13:08:39Z
dc.date.issued2014-07-01
dc.description.abstractPURPOSE: To evaluate the effect of ketamine S (+) 5% with no preservatives and administered as a subarachnoid single puncture on the spinal cord and meninges of rabbits.METHODS: Twenty young adult female rabbits, each weighing 3500-5000 g and having a spine length between 34 and 38 cm, were divided by lot into two groups (G): 0.9% saline in G1 and ketamine S (+) 5% in G2, by volume of 5 μg per cm column (0.18 mL). After intravenous anaesthesia with ketamine and xylazine, the subarachnoid space was punctured at S1-S2 under ultrasound guidance, and a random solution was injected. The animals remained in captivity for 21 days under medical observation and were sacrificed by decapitation. The lumbosacral spinal cord portion was removed for immunohistochemistry to assess the glial fibrillary acidic protein (GFAP), and histology was assessed using hematoxylin and eosin (HE) stain.RESULTS:No histological lesions were found in the nervous tissue (roots and cord) or meninges in either group.CONCLUSION: The ketamine S (+) 5% unpreserved triggered no neurological or histological lesions in the spinal cord or meninges of rabbits.en
dc.description.affiliationPaulista State University Botucatu Medical School
dc.description.affiliationUNESP Botucatu Medical School
dc.description.affiliationUNESP Faculty of Veterinary Medicine and Animal Science Department of Animal Reproduction and Veterinary Radiology
dc.description.affiliationUNESP Botucatu Medical School Department of Pathology
dc.description.affiliationUNESP Botucatu Medical School Department of Dermatology
dc.description.affiliationUNESP Botucatu Medical School Department of Anesthesiology
dc.description.affiliationUnespPaulista State University Botucatu Medical School
dc.description.affiliationUnespUNESP Botucatu Medical School
dc.description.affiliationUnespUNESP Faculty of Veterinary Medicine and Animal Science Department of Animal Reproduction and Veterinary Radiology
dc.description.affiliationUnespUNESP Botucatu Medical School Department of Pathology
dc.description.affiliationUnespUNESP Botucatu Medical School Department of Dermatology
dc.description.affiliationUnespUNESP Botucatu Medical School Department of Anesthesiology
dc.format.extent472-477
dc.identifierhttp://dx.doi.org/10.1590/S0102-86502014000700010
dc.identifier.citationActa Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 29, n. 7, p. 472-477, 2014.
dc.identifier.doi10.1590/S0102-86502014000700010
dc.identifier.fileS0102-86502014000700472.pdf
dc.identifier.issn0102-8650
dc.identifier.lattes7493832230861671
dc.identifier.orcid0000-0001-9596-7289
dc.identifier.scieloS0102-86502014000700472
dc.identifier.urihttp://hdl.handle.net/11449/109898
dc.language.isoeng
dc.publisherSociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.relation.ispartofActa Cirúrgica Brasileira
dc.relation.ispartofjcr0.933
dc.relation.ispartofsjr0,395
dc.rights.accessRightsAcesso aberto
dc.sourceSciELO
dc.subjectAnesthesia, Spinalen
dc.subjectKetamineen
dc.subjectInjections, Spinalen
dc.subjectSpinal Corden
dc.subjectRabbitsen
dc.titleEffects caused by the spinal administration of ketamine S (+) 5% with no preservatives, using a single puncture, and located on the spinal cord and meninges in rabbitsen
dc.typeArtigo
unesp.author.lattes7493832230861671[7]
unesp.author.orcid0000-0001-6947-5627[5]
unesp.author.orcid0000-0001-9596-7289
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina Veterinária e Zootecnia, Botucatupt

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Artigos - Reprodução Animal e Radiologia Veterinária - FMVZ
Artigos - Anestesiologia - FMB
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