Protective effect of safranine on the mitochondrial damage induced by Fe(II)citrate: Comparative study with trifluoperazine

Página do item simplificado
dc.contributor.authorCastilho, R. F.
dc.contributor.authorPereira, R. S. [UNESP]
dc.contributor.authorVercesi, A. E.
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:18:06Z
dc.date.available2014-05-27T11:18:06Z
dc.date.issued1996-08-07
dc.description.abstractIn this study, we show that safranine at the concentrations usually employed as a probe of mitochondrial membrane potential significantly protects against the oxidative damage of mitochondria induced by Fe(II)citrate. The effect of safranine was illustrated by experiments showing that this dye strongly inhibits both production of thiobarbituric acid-reactive substances and membrane potential decrease when energized mitochondria were exposed to Fe(II)citrate in the presence of Ca 2+ ions. Similar results were obtained with the lipophylic compound trifluoperazine. It is proposed that, like trifluoperazine, safranine decreases the rate of lipid peroxidation due to its insertion in the membrane altering the physical state of the lipid phase.en
dc.description.affiliationDepartamento de Bioquímica IB UNICAMP, Campinas, São Paulo
dc.description.affiliationDepartamento de Bioquímica IQ UNESP, Araraquara, São Paulo
dc.description.affiliationDepartamento de Bioquímica IQ UNESP, Araraquara, SP 14801-970
dc.description.affiliationUnespDepartamento de Bioquímica IQ UNESP, Araraquara, São Paulo
dc.description.affiliationUnespDepartamento de Bioquímica IQ UNESP, Araraquara, SP 14801-970
dc.format.extent17-21
dc.identifierhttp://dx.doi.org/10.1007/BF03190273
dc.identifier.citationEuropean Journal of Drug Metabolism and Pharmacokinetics, v. 21, n. 1, p. 17-21, 1996.
dc.identifier.doi10.1007/BF03190273
dc.identifier.issn0378-7966
dc.identifier.scopus2-s2.0-0030036239
dc.identifier.urihttp://hdl.handle.net/11449/64827
dc.identifier.wosWOS:A1996UY20800004
dc.language.isoeng
dc.relation.ispartofEuropean Journal of Drug Metabolism and Pharmacokinetics
dc.relation.ispartofjcr1.362
dc.relation.ispartofsjr0,338
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectFe(II)citrate
dc.subjectMitochondrial damage
dc.subjectSafranine
dc.subjectTrifluoperazine
dc.subjectcalcium ion
dc.subjectdye
dc.subjectferric citrate
dc.subjectsafranin
dc.subjectthiobarbituric acid reactive substance
dc.subjecttrifluoperazine
dc.subjectunclassified drug
dc.subjectanimal tissue
dc.subjectcell membrane potential
dc.subjectcontrolled study
dc.subjectlipid peroxidation
dc.subjectliver mitochondrion
dc.subjectmale
dc.subjectmembrane damage
dc.subjectmitochondrial membrane
dc.subjectnonhuman
dc.subjectrat
dc.subjectAnimals
dc.subjectAntipsychotic Agents
dc.subjectColoring Agents
dc.subjectFerrous Compounds
dc.subjectLipid Peroxidation
dc.subjectMale
dc.subjectMembrane Potentials
dc.subjectMitochondria, Liver
dc.subjectPhenazines
dc.subjectRats
dc.titleProtective effect of safranine on the mitochondrial damage induced by Fe(II)citrate: Comparative study with trifluoperazineen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt

Arquivos

Coleções

Artigos - Bioquímica e Tecnologia - IQ