Non-Ulcerated and Ulcerated Necrotizing Sialometaplasia: Report of an Additional Case and Literature Review

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dc.contributor.authorSilva, Evânio Vilela [UNESP]
dc.contributor.authorSilveira, Heitor Albergoni [UNESP]
dc.contributor.authorMoreira, Thales Peres Candido
dc.contributor.authorAugusto, Jefferson
dc.contributor.authorSilva, Paula Verona Ragusa [UNESP]
dc.contributor.authorBufalino, Andreia [UNESP]
dc.contributor.authorLeón, Jorge Esquiche
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2023-07-29T13:45:13Z
dc.date.available2023-07-29T13:45:13Z
dc.date.issued2023-01-01
dc.description.abstractNecrotizing sialometaplasia (NS) is a rare, self-limiting, necrotizing inflammatory lesion, often involving the minor salivary glands of the palate. NS occurs often in men (60%) older than 45 years. Commonly, it presents as an ulcerative lesion, measuring 1 to 3 cm in diameter, with an evolution time of a few weeks or days, simulating malignancy. However, in some instances, the mucosal surface is intact, thus emphasizing the importance of considering NS in the differential diagnosis of oral ulcerative and non-ulcerative lesions. To date, 12 cases of non-ulcerated NS in the palate have been reported. Here, we report a 50-year-old male patient who presented a non-ulcerated, asymptomatic, nodular swelling 3 months ago, located on the hard palate, clinically suggesting salivary gland tumor or lymphoproliferative disorder. After biopsy, a diagnosis of non-ulcerated NS was established. After 4 weeks, the lesion evolved with complete resolution. After literature review, notably, unlike ulcerated NS, the non-ulcerated NS affected patients a decade younger (33 years vs. 45 years), with marked female predilection (83% vs. 40%) and not uncommon bilateral presentation (33% vs. 10%). NS should be considered in the differential diagnosis of ulcerative and non-ulcerative lesions affecting the palate.en
dc.description.affiliationOral Medicine Department of Diagnosis and Surgery Araraquara Dental School (UNESP)
dc.description.affiliationOral Pathology Department of Stomatology Public Oral Health and Forensic Dentistry Ribeirão Preto Dental School (FORP/USP) University of São Paulo, Avenida do Caf?, S/N, SP
dc.description.affiliationDepartment of Pathology and Forensic Medicine FMRP/USP) Ribeirão Preto Medical School University of São Paulo, SP
dc.description.affiliationUnespOral Medicine Department of Diagnosis and Surgery Araraquara Dental School (UNESP)
dc.identifierhttp://dx.doi.org/10.1007/s12070-023-03609-4
dc.identifier.citationIndian Journal of Otolaryngology and Head and Neck Surgery.
dc.identifier.doi10.1007/s12070-023-03609-4
dc.identifier.issn0973-7707
dc.identifier.issn2231-3796
dc.identifier.scopus2-s2.0-85149627816
dc.identifier.urihttp://hdl.handle.net/11449/248480
dc.language.isoeng
dc.relation.ispartofIndian Journal of Otolaryngology and Head and Neck Surgery
dc.sourceScopus
dc.subjectImmunohistochemistry
dc.subjectNecrotizing sialometaplasia
dc.subjectOral mucosa
dc.subjectPalate
dc.subjectSalivary gland diseases
dc.titleNon-Ulcerated and Ulcerated Necrotizing Sialometaplasia: Report of an Additional Case and Literature Reviewen
dc.typeArtigo
unesp.author.orcid0000-0001-9883-9776[1]
unesp.author.orcid0000-0002-6724-3504[2]
unesp.author.orcid0000-0002-0622-3075[3]
unesp.author.orcid0000-0003-4801-9504[4]
unesp.author.orcid0000-0001-8213-7008[5]
unesp.author.orcid0000-0002-6714-6253[6]
unesp.author.orcid0000-0002-9668-5870[7]

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