Safety evaluation of ondansetron after gestational exposure on male reproductive parameters in rats

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dc.contributor.authorReis, Ana Carolina Casali [UNESP]
dc.contributor.authorJorge, Bárbara Campos [UNESP]
dc.contributor.authorStein, Julia [UNESP]
dc.contributor.authorMoreira, Suyane da Silva [UNESP]
dc.contributor.authorManoel, Beatriz de Matos [UNESP]
dc.contributor.authorAquino, Ariana Musa [UNESP]
dc.contributor.authorValente, Leticia Cardoso
dc.contributor.authorKassuya, Cândida Aparecida Leite
dc.contributor.authorScarano, Wellerson Rodrigo [UNESP]
dc.contributor.authorArena, Arielle Cristina [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionFederal University of Grande Dourados (UFGD)
dc.date.accessioned2023-07-29T13:33:41Z
dc.date.available2023-07-29T13:33:41Z
dc.date.issued2023-01-01
dc.description.abstractOndansetron is a 5HT3 receptor antagonist widely used to treat hyperemesis gravidarum, although its safety is still questionable. Since 5HT3 receptors, which are the target of this drug, can interfere with brain development through changes in neurotransmitter levels, this study evaluated whether the prenatal exposure to this drug could compromise reproductive and behavioral parameters in male offspring. Pregnant rats were treated with ondansetron (1.7 and 2.5 mg/kg/body weight; gavage), from gestational day 1–21. No exposure-related changes in clinical signs, body weight, food consumption, pregnancy length, and necropsy findings were observed in dams. Ondansetron exposure did not alter the anogenital distance or age of preputial separation in male offspring. Similarly, males exposed to therapeutic doses of ondansetron did not exhibit changes in play behavior. In adulthood, there were no changes in sperm parameters, as well as in testosterone level, sexual behavior and fertility. Furthermore, ondansetron did not interfere with testicular and epididymal histology, and with androgen receptor expression in hypothalamus. In conclusion, prenatal exposure to ondansetron did not cause maternal toxicity, as well as did not interfere with reproductive parameters of male offspring, indicating its safety after gestational exposure in rats.en
dc.description.affiliationInstitute of Biosciences of Botucatu Department of Structural and Functional Biology University. Estadual Paulista – Botucatu (UNESP), São Paulo
dc.description.affiliationSchool of Health Sciences Federal University of Grande Dourados (UFGD), MS
dc.description.affiliationCenter of Toxicological Assistance (CEATOX) Institute of Biosciences of Botucatu Univ. Estadual Paulista – Botucatu (UNESP), São Paulo State
dc.description.affiliationUnespInstitute of Biosciences of Botucatu Department of Structural and Functional Biology University. Estadual Paulista – Botucatu (UNESP), São Paulo
dc.description.affiliationUnespCenter of Toxicological Assistance (CEATOX) Institute of Biosciences of Botucatu Univ. Estadual Paulista – Botucatu (UNESP), São Paulo State
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2020/08745–9
dc.identifierhttp://dx.doi.org/10.1016/j.yrtph.2022.105302
dc.identifier.citationRegulatory Toxicology and Pharmacology, v. 137.
dc.identifier.doi10.1016/j.yrtph.2022.105302
dc.identifier.issn1096-0295
dc.identifier.issn0273-2300
dc.identifier.scopus2-s2.0-85144589855
dc.identifier.urihttp://hdl.handle.net/11449/248072
dc.language.isoeng
dc.relation.ispartofRegulatory Toxicology and Pharmacology
dc.sourceScopus
dc.subject5HT3
dc.subjectBrain sexual differentiation
dc.subjectHyperemesis gravidarum
dc.subjectMale rats
dc.subjectPregnancy
dc.titleSafety evaluation of ondansetron after gestational exposure on male reproductive parameters in ratsen
dc.typeArtigo
unesp.author.orcid0000-0002-2373-9399 0000-0002-2373-9399[10]

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Botucatu - CEATOX - Centro de Assistência Toxicológica