Hepatoprotective treatment attenuates oxidative damages induced by carbon tetrachloride in rats

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dc.contributor.authorde Andrade Belo, Marco Antonio
dc.contributor.authorSoares, Vando Edesio [UNESP]
dc.contributor.authorde Souza, Luciano Melo
dc.contributor.authorda Rosa Sobreira, Marcia Ferreira
dc.contributor.authorSilveira Cassol, Daniela Miyasaka
dc.contributor.authorToma, Sandra Barioni
dc.contributor.institutionCamilo Castelo Branco Univ Unicastelo
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionOuro Fino Anim Hlth Co
dc.date.accessioned2014-05-20T13:16:05Z
dc.date.available2014-05-20T13:16:05Z
dc.date.issued2012-03-01
dc.description.abstractThe present study evaluated the hepatoprotective effect of an N-acetyl or-methionine + choline chloride + caffeine + thiamine hydrochloride + nicotinamide + pyridoxine hydrochloride compound at doses of 0.2, 0.6 and 1.0 mL/kg of b.w., and the assessment was done by the investigation of serum-enzymatic activity, metabolic functions of the liver and histophatological changes in female Wistar rats, which were subjected to experimental intoxication with CCl4. One hundred and nineteen rats were randomly distributed into 17 groups, performing five different treatments, being evaluated seven animals per treatment in four periods: 2, 4, 6 and 8 days after CCl4-induced intoxication. Treated rats with the hepatoprotective medicine (HM) presented a significant reduction in infiltration of inflammatory cells, steatosis, necrosis and liver congestion when compared to non-treated rats (control). Beside these results, the treatment showed a positive effect on circulatory alterations in the intoxicated animals, with reduction of spleen and renal congestion, as well as, promotion of a significant improvement in ALT, AST, LDH, ALP, GGT enzymatic serum activity reduction and in recovering liver function regarding the metabolism of urea, triglycerides and glucose. These findings indicate therapeutic usefulness of the compound when administered at dose 0.6 and 1.0 mL/kg of b.w. in female Wistar rats. (C) 2010 Elsevier GmbH. All rights reserved.en
dc.description.affiliationCamilo Castelo Branco Univ Unicastelo, Lab Pharmacol & Clin Pathol, Coll Vet Med, BR-13690000 Descalvado, SP, Brazil
dc.description.affiliationState Univ São Paulo Unesp, Dept Vet Pathol, CPPAR, Jaboticabal, SP, Brazil
dc.description.affiliationOuro Fino Anim Hlth Co, Dept Vet Res, Cravinhos, SP, Brazil
dc.description.affiliationUnespState Univ São Paulo Unesp, Dept Vet Pathol, CPPAR, Jaboticabal, SP, Brazil
dc.description.sponsorshipOuro Fino Animal Health Company
dc.description.sponsorshipCamilo Castelo Branco University (UNICASTELO)
dc.format.extent155-165
dc.identifierhttp://dx.doi.org/10.1016/j.etp.2010.08.001
dc.identifier.citationExperimental and Toxicologic Pathology. Jena: Elsevier Gmbh, Urban & Fischer Verlag, v. 64, n. 3, p. 155-165, 2012.
dc.identifier.doi10.1016/j.etp.2010.08.001
dc.identifier.issn0940-2993
dc.identifier.urihttp://hdl.handle.net/11449/3053
dc.identifier.wosWOS:000302562200004
dc.language.isoeng
dc.publisherElsevier Gmbh, Urban & Fischer Verlag
dc.relation.ispartofExperimental and Toxicologic Pathology
dc.relation.ispartofjcr2.023
dc.relation.ispartofsjr0,551
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectHepatoprotectionen
dc.subjectTreatmenten
dc.subjectIntoxicationen
dc.subjectCarbon tetrachloride (CCl4)en
dc.subjectRatsen
dc.titleHepatoprotective treatment attenuates oxidative damages induced by carbon tetrachloride in ratsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier Gmbh, Urban & Fischer Verlag

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